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时间:2020-05-09
《超声结合血清中CA125对绝经后卵巢恶性肿瘤的诊断价值.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国医药导报2015年3月第12卷第8期·临床医学一肿瘤超声结合血清中CA125对绝经后卵巢恶性肿瘤的诊断价值李华满莉1.辽宁省鞍山市肿瘤医院电诊科,辽宁鞍山114036;2.辽宁省鞍山市肿瘤医院肿瘤内科,辽宁鞍山114036【摘要】目的探讨超声结合血清中CA125对绝经后卵巢恶性肿瘤的诊断价值。方法回顾性分析2012年4月~2014年4月鞍山市肿瘤医院妇产科收治的100例绝经后卵巢肿瘤患者的临床资料,按照检查方法分为超声组(30例)、CA125组(30例)、超声联合CA125组(40例)。所有患者均给予子宫全切除手术或者次全
2、切除手术,且术中进行冰冻切片病理检查.根据病理检查结果观察血清CA125检测的特异性、敏感性。结果超声联合CA125组的确诊率为32.5%,显著高于超声组、CA125组(10%、12%),差异均有统计学意义(P<0.05)。血清中CA125的值以35u,mL为诊断界点时,随着值的增大,卵巢恶性肿瘤发生率显著增高(P<0.05);CA125的诊断界点从35U,mL提高到80U/mL时,诊断特异性从94.8%提高至98.9%,但诊断敏感性从55.6%降低到49.5%;超声下显示为实性的肿瘤,诊断为恶性肿瘤的概率显著增大(P<0.0
3、5)。结论超声诊断结合血清CA125测定对于鉴别诊断绝经后卵巢良恶性肿瘤价值重大。【关键词1超声;CA125;绝经后卵巢恶性肿瘤;诊断价值【中图分类号1R737.31【文献标识码】A【文章编号】1673-7210(2015)o3(b)-0087-04ValueofultrasoundcombinedwithserumCA125inthediagnosispost-menopausalmalignantneoplasmofovaryLlH/A~1MANLi21.DepartmentofElectricalDiagnosis,Tu
4、morHospitalofAnshanCity,LiaoningProvince,Anshan114036,China;2.DepartmentofMedicalOneology,TumorHospitalofAnshanCity,LiaoningProvince,Anshan114036,China[Abstract]ObjectiveTodiscussthevalueofultrasoundcombinedwithserumCA125inthediagnosispostmenopausalmalignantneoplasm
5、ofovary.MethodsClinicaldataof100patientswithpostmenopausalneoplasmofovaryinTumorHospitalofAnshanCityfromApril2012toApril2014wereretrospectiveyanalyzed.Allthepatientsweredividedintotheultrasoundgroup(30cases),CA125group(30cases),andultrasoniccombinedCA125group(40case
6、s)accordingtotheinspectionmethods,allpatientsweregiventotalexcisionsurgeryorsubtotalresectionsurgeryoftheuterine,andfrozensectionpathologicalexaminationwasdoneduringoperation.Accordingtothepathologicexaminationresults,thespecificityandsensitivityofserumCA125detectio
7、nwereobserved.ResultsThepositiverateoftheultrasoniccombinedCA125groupwas32.5%,whichwassignificantlyhigherthantheultrasoundgroupandCA125group(10%,12%),thedifferenceswerestatisticallysignificant(P<0.05).35U/mLwasconductedasthediagnosticpointofCA125,withtheincreasedofl
8、evelofserumCA125,theincidenceofovarianmalignanttumorswassignificantlyincreased(P<0.05);whenthediagnosticpointoftheCA125increasedfrom35U/mL
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