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时间:2020-05-08
《抗感染治疗对乙型肝炎肝硬化并自发性细菌性腹膜炎的影响及分析-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、74·临床论著·抗感染治疗对乙型肝炎肝硬化并自发性细菌性腹膜炎的影响及分析胡蓉曾义岚康信通王丽毛创杰【摘要】目的探讨抗感染治疗对乙型肝炎肝硬化并自发性细菌性腹膜炎(SBP)患者血清降钙素原(PCT)和血清C一反应蛋白(CRP)水平的影响。方法对本院2012年1月至2013年2月所收治的98例乙型肝炎肝硬化患者的临床资料进行回顾性分析。结果乙型肝炎肝硬化患者血清PCT和CRP水平均显著高于对照组,且感染组血清PCT、CRP水平显著高于无感染组(,=4.419、5.807,P2、T水平显著下降(t=6.428、3.513,P<0.05);且经Spearman相关分析,患者血清CRP和PCT水平与SBP的严重程度具有良好的正相关性。结论血清PCT和CRP水平是诊断乙型肝炎肝硬化并SBP的重要指标,抗感染治疗可显著降低PCT和CRP的水平。【关键词】肝硬化;原发性腹膜炎;降钙素原;C一反应蛋白Affectandanalysisofanti.infectiontreatmentforpatientswithHBV-relatedlivercirrhosiscomplicatedwithsponte3、nousbacterialperitonitisHURong,ZENGYilan,KANGXintong,WANGLi,MAOChuangjie.ChengduPublicHealthClinicalMedicalCenter,Chengdu610000,ChinaCorrespondingauthor."KANGXintong,Email:282932166@qq.corn【Abstract]ObjectiveToinvestigatetheinfluenceofanti—infectiontreatmentonl4、evelsofserumprocalcitonin(PCT)andserumC—reactiveprotein(CRP)inpatientswithHBV-relatedlivercirrhosiscomplicatedwithspontaneousbacterialperitonitis(SBP).MethodsTheclinicaldataof98patientswithHBV-relatedlivercirrhosisinourhospitalfromJanuary2012toFebruary2013werea5、nalyzed,retrospectively.ResultsThelevelsofserumPCTandCRPofpatientswithHBV-relatedlivercirrhosisweresignificantlyhigherthanthoseincontrolgroup.ThelevelsofserumPCTandCRPofpatientsininfectiongroupweresignificantlyhigherthanthosewithoutinfection(F4.419,5.807;P<0.056、).Aftertreatment,thelevelsofserumPCTandCRPinpatientswithinfectionweredecreasedsignificantly(t6.428,3.513;P<0.05).WhilebytheSpearmancorrelationanalysis,thelevelsofserumCRPandPCTandtheseverityoftheSBPhadgoodpositivecorelations.ConclusionsThelevelsofserumPCTandCRP7、areimportantindicatorsfordiagnosisofHBV-relatedlivercirhosiscomplicatedwithSBP.Anti—infectiontreatmentcouldsignificantlyreducethelevelsofPCTandCRP.【Keywords】Livercirrhosis;Spontenousbacterialperitonitis;Procalcitonin;C—reactiveprotein自发性细菌性腹膜炎(spontaneousbacter8、ial率仍高达20%~30%,肝功能损害严重者病死率更peritonitis,SBP)是乙型肝炎肝硬化患者失代偿期高。因而,早期诊断和经验性抗感染药物的治疗对常见的严重并发症之一,易导致病情恶化,严重患者的预后极为重要,本研究对本院2012年1月至者可引发患者死亡⋯。据调查数据显示,在积极2013年2月收治的乙型肝炎肝硬化并发原发性腹膜治疗的前
2、T水平显著下降(t=6.428、3.513,P<0.05);且经Spearman相关分析,患者血清CRP和PCT水平与SBP的严重程度具有良好的正相关性。结论血清PCT和CRP水平是诊断乙型肝炎肝硬化并SBP的重要指标,抗感染治疗可显著降低PCT和CRP的水平。【关键词】肝硬化;原发性腹膜炎;降钙素原;C一反应蛋白Affectandanalysisofanti.infectiontreatmentforpatientswithHBV-relatedlivercirrhosiscomplicatedwithsponte
3、nousbacterialperitonitisHURong,ZENGYilan,KANGXintong,WANGLi,MAOChuangjie.ChengduPublicHealthClinicalMedicalCenter,Chengdu610000,ChinaCorrespondingauthor."KANGXintong,Email:282932166@qq.corn【Abstract]ObjectiveToinvestigatetheinfluenceofanti—infectiontreatmentonl
4、evelsofserumprocalcitonin(PCT)andserumC—reactiveprotein(CRP)inpatientswithHBV-relatedlivercirrhosiscomplicatedwithspontaneousbacterialperitonitis(SBP).MethodsTheclinicaldataof98patientswithHBV-relatedlivercirrhosisinourhospitalfromJanuary2012toFebruary2013werea
5、nalyzed,retrospectively.ResultsThelevelsofserumPCTandCRPofpatientswithHBV-relatedlivercirrhosisweresignificantlyhigherthanthoseincontrolgroup.ThelevelsofserumPCTandCRPofpatientsininfectiongroupweresignificantlyhigherthanthosewithoutinfection(F4.419,5.807;P<0.05
6、).Aftertreatment,thelevelsofserumPCTandCRPinpatientswithinfectionweredecreasedsignificantly(t6.428,3.513;P<0.05).WhilebytheSpearmancorrelationanalysis,thelevelsofserumCRPandPCTandtheseverityoftheSBPhadgoodpositivecorelations.ConclusionsThelevelsofserumPCTandCRP
7、areimportantindicatorsfordiagnosisofHBV-relatedlivercirhosiscomplicatedwithSBP.Anti—infectiontreatmentcouldsignificantlyreducethelevelsofPCTandCRP.【Keywords】Livercirrhosis;Spontenousbacterialperitonitis;Procalcitonin;C—reactiveprotein自发性细菌性腹膜炎(spontaneousbacter
8、ial率仍高达20%~30%,肝功能损害严重者病死率更peritonitis,SBP)是乙型肝炎肝硬化患者失代偿期高。因而,早期诊断和经验性抗感染药物的治疗对常见的严重并发症之一,易导致病情恶化,严重患者的预后极为重要,本研究对本院2012年1月至者可引发患者死亡⋯。据调查数据显示,在积极2013年2月收治的乙型肝炎肝硬化并发原发性腹膜治疗的前
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