拉米夫定联合膈下逐瘀汤对乙型肝炎肝硬化治疗的临床疗效评价-论文.pdf

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1、·3706·中华医院感染学杂志2014年第24卷第15期ChinJNosoeomiolVo1．24No．152014doi：10．11816／cn．ni．2014—134539论著拉米夫定联合膈下逐瘀汤对乙型肝炎肝硬化治疗的临床疗效评价韩曼珠，王芬，李丽，卢碧雪(海南省中医院脾胃肝病科，海南海口570203)摘要：目的观察拉米夫定联合膈下逐瘀汤治疗乙型肝炎肝硬化的效果，以改善肝功能。方法选取2009年1月5O例乙型肝炎肝硬化患者，分为治疗组与对照组，各25例；治疗组应用拉米夫定联合膈下逐瘀汤治疗；对照组单用拉米夫定进行治疗；观察并比较两组在治疗前后肝功能、肝纤维化指标、门静脉血流动力学、血清H

2、BV-DNA等，并进行Child—Pugh分级评分，应用SPSS13．0软件进行统计分析。结果经过治疗两组患者的肝功能指标明显改善，肝纤维化指标有所下降，门静脉血流动力学的指标也明显改善，HBV-DNA载量下降，Child—Pugh评分有所下降，对照组由(9．3±2．6)分降至(6．2±2．1)分；与对照组相比，治疗组在以上各项指标的改善均更加明显，Child—Pugh评分治疗组为(6．2±2．1)分，对照组为(8．1±2．4)分，差异均有统计学意义(P

3、类号：R978．1文献标识码：A文章编号：1005—4529(2014)15-3706—03ClinicaleffectevaluationoflamivudinecombinedwithgexiazhuyusoupintreatmentofHBV—inducedlivercirrhosisHANMan—zhu，WANGFen，LILi，LUBi—xue(TraditionalChineseMedicineHOSpital0fHainanProvince，Haikou，Hainan570203，China)Abstract：OBJECTIVEToobservetheeffectoflamivu

4、dinecombinedwithgexiazhuyusoupintreatmentofHBV-induced1ivercirrhosistOimprove1iverfunction．METHODSTotally50patientswithHBV-inducedlivercirrhosisinourhospitalinJan．2009wereselectedanddividedintothetreatmentgroupandthecontrolgroup，eachgroupwith25patients．Thetreatmentgroupreceivedcombinedtreatmentoflam

5、ivudinewithgexiazhuyusoup，whilethecontrolgroupreceivedlamivudineonly．ThetWOgroupswereobservedforthechangesofliverfunctionbeforeandaftertreatment，theindicatorof1iverfibrosis，portalveinhemodynamics，andHBv_DNA，werescoredwiththeChild-Pughgrading．ThestatisticalanalysiswasconductedwithSPSS13．0．RESULTSAfte

6、rthetreatment，liverfunctionandtheindicatorforportalveinhemodynamicsweresignificantlyimprovedandtheindicatorofliverfibro—sis，HBV-DNAloadingcapacityandChild—Pughscoresweredeceasedatcertaindegrees．TheChild—Pughscorewasdecreasedfrom(9．3土2．6)tO(6．2±2．1)inthecontrolgroup．Comparedwiththecontrolgroup，theimp

7、rovementoftheaboveindicatorsintreatmentgroupwasmoreobvious．TheChild—Pughscorewas(6．2-t-2．1)inthetreatmentgroupand(8．1士2．4)inthecontrolgroupwithsignificantdifference(P