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时间:2020-05-08
《CRRT联合PE治疗晚期重症肝炎合并肝肾综合征的疗效观察-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华医院感染学杂志2014年第24卷第5期ChinJNosocomiolVo1.24No.52014doi:10.11816/cn.ni.2014—131991论著CRRT联合PE治疗晚期重症肝炎合并肝肾综合征的疗效观察高海丽,王新伟,梁海军,杨道坤,乔汉臣(新乡医学院第一附属医院感染疾病科,河南卫辉453100)摘要:目的观察连续性肾脏替代疗法(CRRT)与血浆置换(PE)联合治疗晚期重症肝炎患者合并肝肾综合征(HRS)的疗效。方法选择医院收治的6O例晚期重症肝炎合并肝肾综合征患者随机分为观察组和对照组
2、各30例,对照组行常规治疗,观察组除常规治疗外给予CRRT与PE联合治疗;数据采用SPSS13.0统计软件进行统计分析。结果治疗前两组尿素氮(BUN)、肌酐(Cr)、总胆红素(TBIL)、血氮(NH。)、血清白蛋白(ALB)、胆碱酯酶(CHE)、血钠(Na)、血钾(K)比较,差异无统计学意义;治疗后血清K、BUN、Cr、NH3、TBIL观察组分别为(3.78_4-0.43)mmol/L、(8.90±2.47)mmol/L、(145.86土65.11)~mol/L、(104.34士35.57)~mol/L、
3、(387.43土97.90)fmol/L,明显低于对照组的(4.65±0.56)mmol/L、(12.21±3.21)mmol/L、(224.554-91.32)/lmol/I、(145.32士4l_45)mol/L、(494.12±132.65)mol/L(P<0.01);而血Na、ALB、CHE观察组分别为(131.34士7.11)mmol/L、(32.79-4-3.54)g/L、(445.76±123.56)U/L,明显高于对照组的(125.73±7.44)mmol/L、(29.53土3.76)g/
4、L、(343,78±90.77)U/L(P<0.05);观察组死亡9例;对照组死亡2O例;两组患者比较,差异有统计学意义(P5、withhepatorenalsyndromeGAOHai—li,WANGXin—wei,LIANGHai—iun,YANGDao—kun,QIAOHan—chen(TheFirstAL厂filiatedHospitalofXinxiangMedicalCollege,,Henan453100,China)Abstract:OBJECTIVEToobservetheclinicalefficacyofcontinuousrenalreplacementtherapy(CRRT)combinedwithpl6、asmaexchange(PE)intreatmentofadvancedseverehepatitiscomplicatedwithhepatorenalsyndrome(HRS).METHODSTotally60casesofadvancedseverehepatitispatientscomplicatedwithHRSwererecruitedfromthehospitalandrandomlydividedintotheobservationgroupandthecontrolgroup,wit7、h30casesineach,thenthecontrolgroupwastreatedwiththeconventionaltherapy,theobservationgroupwasgivenadditionalCRRTcombinedwithPEonthebasisoftheconventionaltherapy;thedatawerestatisticallyanalyzedwithSPSS13.0software.RESULTSComparedwiththeureanitrogen(BUN),c8、reatinine(SCr),totalbilirubin(TBIL),nitrogen(NH),serumalbumin(ABL),cholinesterase(CHE),Na,orKbeforethetreatment,thedifferencebetweenthetwogroupswasnotstatisticallysignificant;afterthetreatment,thelevelsofserumK,BUN,
5、withhepatorenalsyndromeGAOHai—li,WANGXin—wei,LIANGHai—iun,YANGDao—kun,QIAOHan—chen(TheFirstAL厂filiatedHospitalofXinxiangMedicalCollege,,Henan453100,China)Abstract:OBJECTIVEToobservetheclinicalefficacyofcontinuousrenalreplacementtherapy(CRRT)combinedwithpl
6、asmaexchange(PE)intreatmentofadvancedseverehepatitiscomplicatedwithhepatorenalsyndrome(HRS).METHODSTotally60casesofadvancedseverehepatitispatientscomplicatedwithHRSwererecruitedfromthehospitalandrandomlydividedintotheobservationgroupandthecontrolgroup,wit
7、h30casesineach,thenthecontrolgroupwastreatedwiththeconventionaltherapy,theobservationgroupwasgivenadditionalCRRTcombinedwithPEonthebasisoftheconventionaltherapy;thedatawerestatisticallyanalyzedwithSPSS13.0software.RESULTSComparedwiththeureanitrogen(BUN),c
8、reatinine(SCr),totalbilirubin(TBIL),nitrogen(NH),serumalbumin(ABL),cholinesterase(CHE),Na,orKbeforethetreatment,thedifferencebetweenthetwogroupswasnotstatisticallysignificant;afterthetreatment,thelevelsofserumK,BUN,
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