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时间:2020-05-08
《慢性阻塞性肺疾病急性加重期患者低分子肝素抗凝治疗效果评价-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、西部医学2014年9Yl第26卷第9期MedJWestChina,September2014,Vo1.26,No.9慢性阻塞性肺疾病急性加重期患者低分子肝素抗凝治疗效果评价黄艳,乔岩,王清波(1.南京市第二医院,江苏南京210003;2.南京市第一医院,江苏南京210006)【摘要】目的探讨低分子肝素治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的剂量强度与疗效的关系。方法将2008年8月~2009年8月在南京市第一医院治疗的l17例AECOPD患者随机分为3组应用不同剂量低分子肝素进行治疗,A组:6OIU/kg,皮下注射,每天2次,间隔12小时;B组:8OIU/kg,皮下注射,每天
2、2次,问隔12小时;C组;100IU/kg,皮下注射,每天2次,间隔12小时,比较3组间疗效及不良反应发生情况。结果不同剂量的低分子肝素均具有良好疗效,3组患者的各指标变化均具有统计学差异(均P<0.05或P<0.01);B、C两组效果相较于A组均具有统计学差异(均P3、hetherapeuticeffectoflowmolecularweightheparininpatientswithacuteexacerbationofchronicobstructivepulmonarydiseaseHUANGYan,QIAOYan,WANGQing-bo(1.DepartmentofRespiration,TheSecondPeople'sHospitalofNaing,Naing210003;Z.DepartmentofAged,TheSecondPeople'sHospitalofNanjing,Nanjing210003)[Abstract]Object4、iveToanalyzelowmolecularweightheparinintreatmentofacuteexacerbationsofchronicob—structivepulmonarydisease(AECOPD)doseresponserelationship.Methods117casesofAECOPDwererandomlydi—videdintothreegroupswithdifferentdosesoflowmolecularheparintreatment.GroupA:60IU/kg,subcutaneousinjec—tion,2timesaday,12h5、interval;groupB,80IU/kg,subcutaneousinjection,2timesaday,12hinterval;groupC,100IU/kg,subcutaneousinjection,2timesaday,12hinterva1.Thetherapeuticeffectandadversereactionwereob—served.ResultsDifferentlowmolecularweightheparindosehadgoodcurativeeffect(P<0.05,P6、gnificanteffectcomparedwiththeAgroup(P<0.05).Therewere3casesofadversereactionofplateletdecreasedinCgroup.ConclusionTheuseof80IU/kgdoseofheparinonAECOPDremissionhasgoodeffectsandnosideeffects.[Keywords]Lowmolecularweightheparin;Acuteexacerbation;Chronicobstructivepulmonarydisease;Adversereaction慢性7、阻塞性肺疾病(Chronicobstructivepulmo—COPD)患者进行分析,现将结果报告如下。narydisease,COPD)在我国40岁以上人群中患病率1资料与方法高达8.2,其发病率高,病情严重,可导致肺心病右1.1一般资料本研究1l7例患者均为南京市第一心衰竭甚至全心衰竭,临床上病情危重,呈II型呼吸医院收治的AECOPD患者,随机分为A、B、C3组,每衰竭状态,易致肺性脑病甚至猝死,居全球死亡原因组39例。3组间
3、hetherapeuticeffectoflowmolecularweightheparininpatientswithacuteexacerbationofchronicobstructivepulmonarydiseaseHUANGYan,QIAOYan,WANGQing-bo(1.DepartmentofRespiration,TheSecondPeople'sHospitalofNaing,Naing210003;Z.DepartmentofAged,TheSecondPeople'sHospitalofNanjing,Nanjing210003)[Abstract]Object
4、iveToanalyzelowmolecularweightheparinintreatmentofacuteexacerbationsofchronicob—structivepulmonarydisease(AECOPD)doseresponserelationship.Methods117casesofAECOPDwererandomlydi—videdintothreegroupswithdifferentdosesoflowmolecularheparintreatment.GroupA:60IU/kg,subcutaneousinjec—tion,2timesaday,12h
5、interval;groupB,80IU/kg,subcutaneousinjection,2timesaday,12hinterval;groupC,100IU/kg,subcutaneousinjection,2timesaday,12hinterva1.Thetherapeuticeffectandadversereactionwereob—served.ResultsDifferentlowmolecularweightheparindosehadgoodcurativeeffect(P<0.05,P6、gnificanteffectcomparedwiththeAgroup(P<0.05).Therewere3casesofadversereactionofplateletdecreasedinCgroup.ConclusionTheuseof80IU/kgdoseofheparinonAECOPDremissionhasgoodeffectsandnosideeffects.[Keywords]Lowmolecularweightheparin;Acuteexacerbation;Chronicobstructivepulmonarydisease;Adversereaction慢性7、阻塞性肺疾病(Chronicobstructivepulmo—COPD)患者进行分析,现将结果报告如下。narydisease,COPD)在我国40岁以上人群中患病率1资料与方法高达8.2,其发病率高,病情严重,可导致肺心病右1.1一般资料本研究1l7例患者均为南京市第一心衰竭甚至全心衰竭,临床上病情危重,呈II型呼吸医院收治的AECOPD患者,随机分为A、B、C3组,每衰竭状态,易致肺性脑病甚至猝死,居全球死亡原因组39例。3组间
6、gnificanteffectcomparedwiththeAgroup(P<0.05).Therewere3casesofadversereactionofplateletdecreasedinCgroup.ConclusionTheuseof80IU/kgdoseofheparinonAECOPDremissionhasgoodeffectsandnosideeffects.[Keywords]Lowmolecularweightheparin;Acuteexacerbation;Chronicobstructivepulmonarydisease;Adversereaction慢性
7、阻塞性肺疾病(Chronicobstructivepulmo—COPD)患者进行分析,现将结果报告如下。narydisease,COPD)在我国40岁以上人群中患病率1资料与方法高达8.2,其发病率高,病情严重,可导致肺心病右1.1一般资料本研究1l7例患者均为南京市第一心衰竭甚至全心衰竭,临床上病情危重,呈II型呼吸医院收治的AECOPD患者,随机分为A、B、C3组,每衰竭状态,易致肺性脑病甚至猝死,居全球死亡原因组39例。3组间
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