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时间:2020-05-07
《当归补血汤及拆方对大鼠免疫性肝损伤的治疗作用-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、南京中医药大学学报2014年3月第3O卷第2期一150一JCI_RNALOFNANJINGUNIVERSITYOF7UMVolSONo2Mar.彻4当归补血汤及拆方对大鼠免疫性肝损伤的治疗作用孙丽霞,方南元,周玲玲。,柳璋璞(1.南京中医药大学附属医院,江苏南京210029;2.南京中医药大学药学院,江苏南京210023)摘要:目的观察当归补血汤及拆方对免疫性肝损伤大鼠的肝功能、肝纤维化的影响。方法采用猪血清腹腔给药方法,造成免疫性肝损伤模型,检测大鼠血清中丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、超
2、氧化物歧化酶(SOD)、脂质过氧化物丙二醛(MDA)、透明质酸(HA)、IV型胶原、III型前胶原。结果黄芪/当归5:1组可明显降低猪血清所致免疫性肝损伤大鼠的血清AST、ALT含量;黄芪组、当归组及黄芪当归不同配比组均能升高s0D水平,降低MDA的含量;黄芪组能明显降低HA、IV型胶原;当归补血汤5:1组能明显降低III型前胶原水平,且优于10:1组。结论当归补血汤对免疫性大鼠肝损伤模型具有一定保护作用,其作用机制可能与降低、抑制脂质过氧化反应以及抗自由基损伤有关。关键词:当归补血汤;大鼠;免疫性肝损伤;药效
3、学;模型中图号:文献标志码:A文章编号:1672—0482(2014)O2—0150—03TherapeuticEffectsofDangguiBuxueDecoctionanditsDecompositiononRatswithImmunologicalLiverInjurySUNLi—xia,FANGNan—yuan,ZHOULing—Ling。,LIUZhang—pu(1.TheAffiliatedHospitalofNanjingUniversityofChineseMedicine,Nanjing,2
4、10029,China2.SchoolofPharmacyNanjingUniversityofChineseMedicine,Nanjing,210023,China)ABSTRACT:OBJECTIVEToobserveeffectsofDangguiBuxueDecoctionandthecompositiononliverfunctionandliverfi—brosisinratswithimmunologicalliverinjury.METHODSTheimmunologicalliverinju
5、rymodelswereestablishedwithintra—peritonealadministrationofpigserum,whosealanineaminotransferase(ALT),aspartateaminotransferase(AST),superoxidedismutase(SOD),lipidperoxidemalondialdehyde(MDA),Hyaluronicacid(HA),IVcollagenandIIIprocollagenweredetec—ted.RESULT
6、SThegroupwithratioofAstragalusroottOChineseangelica5:1significantlydecreasedASTandALTlevels;Astragalusrootgroup,ChineseangelicagroupandgroupswithdifferentratiosofAstragalusroottOChineseangelicaincreasedSODlevelsanddecreasedMDAcontent;Astragalusrootgroupobvio
7、uslyreducedHAandtype—IVcollagen;DangguiBuxueDecoctiongroupwiththeratio5:1significantlyreducedtype—IIIprocollagenlevels,superiortOthatingroupwithratio10:1.CONCLUSIONDangguiBuxueDecoctionmakesacertaineffectonratswithimmunologicalliverinjury.whosemechanismmaybe
8、relatedtoreductionandinhibitionoflipidperoxidationandanti—freeradicaldamage.KEYWORDS:DangguiBuxueDecoction;rat;immunologica11iveri~ury;pharmacodynamics;model金元时期李东垣所创的“当归补血汤”,由黄芪免疫性肝损伤的防治作用及相关机制
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