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《幽门螺杆菌感染对慢性乙型肝炎患者治疗的影响研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、中华医院感染学杂志2014年第24卷第15期ChinJNosocomiolVo1.24No.152014·3773·doi:10.11816/cn.ni.2014—135046论著幽门螺杆菌感染对慢性乙型肝炎患者治疗的影响研究卓如平,吴金明,陈旭鹏(1.温卅I医科大学附属乐清医院消化内科,浙江乐清325600;2.温州医科大学附属第一医院消化内科,浙江温州325000)摘要:目的观察慢性乙型肝炎患者幽门螺杆菌(Hp)的感染状况,并探讨其临床意义。方法选取2009年2月一2012年l1月医院门诊或住院部收治的慢性乙型肝炎患者共52例,患
2、者入院后通过酶联免疫吸附试验对血清乙型肝炎病毒(HBV)进行检测,同时采用聚合酶链反应进行HBV-DNA测定确定HBV感染,其中HBV—DNA阳性组为37例,HBV-DNA阴性组为15例;幽门螺杆菌检测中采用血清学、“c呼气试验以及组织学染色、细菌培养等方法进行。结果慢性乙型肝炎患者Hp感染为34例,感染率为65.4,其中HBV—DNA检测阳性37例患者中Hp感染28例,感染率为75.60A,HBV—DNA检测阴性的15例患者中Hp感染6例,感染率为40.0,对比结果差异有统计学意义(P3、具有较高的Hp感染率,同时也是此类患者出现消化性溃疡的重要原因,加强对其的检测分析对临床治疗和预后具有积极指导意义。关键词:慢性乙型肝炎;幽门螺杆菌;消化性溃疡;临床意义中图分类号:R512.62文献标识码:A文章编号:1005—4529(2014)15-3773—03EffectofHelicobacterpyloriinfectionontreatmentofpatientswithchronichepatitisBZHUORu—ping,WUJin—ming,CHENXu—peng(*YueqingHospitalAffilia4、tedtoWenzhouMedicalUniversity,Yueqing,Zejiang325600,China)Abstract:OBJECTIVEToobservetheincidenceofHelicobacterpyloriinfectionsinthepatientswithchronichepatitisBandexploreitsclinicalsignificance.METHODSAtotalof52patientswithchronichepatitisBwhoweretreatedintheoutpatient5、departmentorinpatientdepartmentfromFeb2009toNov2012wereenrolledinthestud—y.AftertheadmissiontOhospital,theserumhepatitisBvirus(HBV)wasdetectedbyusingenzyme—linkedimmu7nosorbentassay,theHBV—DNAwasdeterminedwiththeuseofpolymerase—chain—reactionSOastoconfirmtheHBVinfection6、;thepositiveHBV-DNApositivegroupincluded37cases,thenegativeHBV—DNApositivegroup15cases;theserologicaltest,carbon14breathtest,histologicalstaining,andbacterialculturewereperformedforthedetectionofH.pylori.RESULTSTheH.pyloriinfectionoccurredin34chronichepatitisBpatientswi7、ththeinfectionrateof65.4,including28of37(75.6)patientswithHBV-DNAtestedpositiveand6of15(40.0)ofpatientswithHBV-DNAtestednegative,andtherewasstatisticallydifference(P<0.05).CONCLUSIONTheincidenceofH.pyloriinfectionishighinthepatientswithchronichepatitisBduringtheclini—ca8、ltreatment,whichisaleadingcauseofpepticulcer.ItisofgreatsignificancetOtheclinicaltreatmentandprog—nosistostren
3、具有较高的Hp感染率,同时也是此类患者出现消化性溃疡的重要原因,加强对其的检测分析对临床治疗和预后具有积极指导意义。关键词:慢性乙型肝炎;幽门螺杆菌;消化性溃疡;临床意义中图分类号:R512.62文献标识码:A文章编号:1005—4529(2014)15-3773—03EffectofHelicobacterpyloriinfectionontreatmentofpatientswithchronichepatitisBZHUORu—ping,WUJin—ming,CHENXu—peng(*YueqingHospitalAffilia
4、tedtoWenzhouMedicalUniversity,Yueqing,Zejiang325600,China)Abstract:OBJECTIVEToobservetheincidenceofHelicobacterpyloriinfectionsinthepatientswithchronichepatitisBandexploreitsclinicalsignificance.METHODSAtotalof52patientswithchronichepatitisBwhoweretreatedintheoutpatient
5、departmentorinpatientdepartmentfromFeb2009toNov2012wereenrolledinthestud—y.AftertheadmissiontOhospital,theserumhepatitisBvirus(HBV)wasdetectedbyusingenzyme—linkedimmu7nosorbentassay,theHBV—DNAwasdeterminedwiththeuseofpolymerase—chain—reactionSOastoconfirmtheHBVinfection
6、;thepositiveHBV-DNApositivegroupincluded37cases,thenegativeHBV—DNApositivegroup15cases;theserologicaltest,carbon14breathtest,histologicalstaining,andbacterialculturewereperformedforthedetectionofH.pylori.RESULTSTheH.pyloriinfectionoccurredin34chronichepatitisBpatientswi
7、ththeinfectionrateof65.4,including28of37(75.6)patientswithHBV-DNAtestedpositiveand6of15(40.0)ofpatientswithHBV-DNAtestednegative,andtherewasstatisticallydifference(P<0.05).CONCLUSIONTheincidenceofH.pyloriinfectionishighinthepatientswithchronichepatitisBduringtheclini—ca
8、ltreatment,whichisaleadingcauseofpepticulcer.ItisofgreatsignificancetOtheclinicaltreatmentandprog—nosistostren
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