奥曲肽与垂体后叶素治疗肝硬化上消化道出血的临床效果比较-论文.pdf

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1、中国当代医药2014年10月第21卷第28期·药物与临床·奥曲肽与垂体后叶素治疗肝硬化上消化道出血的临床效果比较王家芳肖承文江西省樟树市江西康宁医院消化内科，江西樟树331211[摘要】目的比较奥曲肽与垂体后叶素治疗肝硬化并发上消化道出血的临床效果。方法将本院2011年5月～2013年12月收治的76例肝硬化并发上消化道出血患者分成治疗组39例和对照组37例。对照组给予常规治疗加垂体后叶素治疗，治疗组给予常规治疗联合奥曲肽治疗，连续使用7d，比较两组的临床疗效和不良反应。结果治疗组的总有效率为94．9％，对照组为64．9

2、％，两组比较，差异有统计学意义(19<0．O1)。治疗组出现呕吐2例、腹痛2例，不良反应发生率为10．2％，对照组出现呕吐3例，恶心1例，腹痛4例，高血压4例，头痛2例，不良反应发生率为37．8％，两组比较，差异有统计学意义(P=O．005)。结论奥曲肽治疗肝硬化并发上消化道出血的临床效果优于垂体后叶素，不良反应少。可在临床推广。【关键词】肝硬化；上消化道出血；奥曲肽；垂体后叶素【中图分类号】R575．2[文献标识码】A【文章编号】1674-4721(2014)10(a)-0071-03Comparisionofclin

3、icalefectofoctreotideandpituitrinintreatmentoflivercirrhosiscomplicatedwithupperdigestivetracthemorrhageWANGfla-fangXIA0Cheng-wenDepartmentofGastroenterology，JiangxiKangningHospitalofZhangshuCityinJiangxiProvince，Zhangshu331211，China【Abstract】ObjectiveTocompareth

4、eclinicaleffectofoctreotideandpituitrinintreatmentoflivercirrhosiscompli—catedwithupperdigestivetracthemorrhage．Methods76patientswithlivercirrhosiscomplicatedwithupperdigestivetracthemorhagetreatedinourhospitalfromMay2011toDecember2013weredividedintothetreatmentg

5、roup(n=39)andcontrolgroup(n=37)．Thecontrolgroupwasgivenconventionaltherapyplusingpituitrin，thetreatmentgroupwasgivenconventionaltreatmentcombinedwithoctreotide，drugswereusedcontinuouslyfor7days．Clinicalcurativeeffectandadversereactionofthetwogroupswerecompared．Re

6、sultsThetotaleffectiverateofthetreatmentgroupwas94．9％，anditwas64．9％inthecontrolgroup，andtherewasastatisticaldifferenceofthetwogroups(P<0．O1)．Therewere2caseswithvomiting．2caseswithabdomina1pain，theincidencerateofadversereactionwas10．2％，andtherewere3caseswithvomiti

7、ng，1casewithnausea，4caseswithabdominalpain，2caseswithheadache，4caseswithhyper—tension,theincidencerateofadversereactionwas37．8％，andtherewasastatisticaldifferenceoftheincidencerateofadversereactioninthetwogroupsf尸=：0．OO5)．ConclusionTheclinicaleffectofoctreotidetre

8、atinglivercirhosiseom—plicatedwithupperdigestivetracthemorhageisbetterthanpituitrinwithlessadversereaction，anditcanbepopular。izedinclinic．【Keywords】Cirhosis；Up