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时间:2020-05-07
《HBsAg阳性肝硬化患者血小板数与肝组织纤维化程度的相关性-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、中国热带医学2014年第14卷第o6期ChinaTropicalMedicine,June2014,Vo1.14,No.06·723··论HBsAg阳性肝硬化患者血小板数与肝组织纤维化程度的相关性吴清花,吴映娥,林静华汕头大学医学院第一附属医院检验科,广东汕头515041摘要:目的探讨分析HBsAg阳性肝硬化患者血小板数及其他参数与肝组织纤维增生的关系。方法分别选择乙肝组58例,、肝硬化组109例,以及对照组60例。采用全自动血常规分析仪SysmexXE一2100检测血小板计数(PLT)1)A及其他参数:平
2、均血小板体积(MPV)、血小板分布宽度(PDW)。结果肝硬化组PLT数[(89.9+43.5)~109/~明显低于乙肝组[(115+59)x10'/L]和健康对照组[(176-+55)x10VL](R0.01)。在肝硬化组内,PLT数随着肝组织纤维化程度增加呈明显下降,sl—S4期分别为:(166.2~31.9)~109/L,(147.4~34.0)x109/L,(113.8~30.4)x109/L,(89.9~19.o)xl09/L,差异有统计学意义(P<0.01),MPV随着肝组织纤维化程度增加呈明显增
3、大,sl—S4期分别为(9.1±1.3),(9.4~0_8),(9.8~0.9),(10.1~0.8),(P<0.05),PDW只有s4与s3之间有统计学意义(P4、essmentofhepatictissuefibrosisinHBsAgpositivecirrhosiscasesWUQing—hua,WUYing-e,LINJing—huaLaboratoryDepartmentofFirstAffiliatedHospitalofShantouUniversi~MediclCollege,Shantou515041,Guangdong,P.R.ChinaAbstract:ObjectiveToanalyzecorrelationofthelevelsofplate5、letandparametersinlivercirrhosispatientswiththeseverityofhepaticfibrosis.MethodsFifty-eighthepatitisBcasesaged19-68years(hepatitisBgroup),109cirrhosiscasesaged21-72years(cirrhosisgroup)and60healthcontrolaged23-65years(controlgroup)wereselectedandthelevelso6、fplateletandotherparametersofPDWandMPVinthecasesofthreegroupsweredeterminedwithassistanceofautomatichematocyteanalyzer(SysmexXE一2100).ResultsThenumberofPLTincirhosisgroupWas【(89.9±43.5)X10VL],significantlylowerthanthat【(115~59)x109/L]inHepatitisBgroupand[(7、176_+55)x10VL]inhealthycontrolgroup(P<0.05).Thenumberofplateletdecreasedalongwithprogressoflivercirhosis(RO.05).TheplateletlevelsatstagingIS1),stagingII(SII),stagingIII(SIII)andstagingIV(SIV)wereasthefollows:(166.2~31.9)X109/L,(147.4~34.0)X109/L,(113.8~30.8、4)×10/L,(89.9±19.0)×109/L,showingsignificantdifference(0.01).TheMPVWasenlargedwiththeprogressofseverityofhepaticfibrosis.WhilePDWshowedsignificantdifferenceatSI(9.1±1.3,9.4~0.8)andSIVstaging,(9.8-+0.9,10.1±O.
4、essmentofhepatictissuefibrosisinHBsAgpositivecirrhosiscasesWUQing—hua,WUYing-e,LINJing—huaLaboratoryDepartmentofFirstAffiliatedHospitalofShantouUniversi~MediclCollege,Shantou515041,Guangdong,P.R.ChinaAbstract:ObjectiveToanalyzecorrelationofthelevelsofplate
5、letandparametersinlivercirrhosispatientswiththeseverityofhepaticfibrosis.MethodsFifty-eighthepatitisBcasesaged19-68years(hepatitisBgroup),109cirrhosiscasesaged21-72years(cirrhosisgroup)and60healthcontrolaged23-65years(controlgroup)wereselectedandthelevelso
6、fplateletandotherparametersofPDWandMPVinthecasesofthreegroupsweredeterminedwithassistanceofautomatichematocyteanalyzer(SysmexXE一2100).ResultsThenumberofPLTincirhosisgroupWas【(89.9±43.5)X10VL],significantlylowerthanthat【(115~59)x109/L]inHepatitisBgroupand[(
7、176_+55)x10VL]inhealthycontrolgroup(P<0.05).Thenumberofplateletdecreasedalongwithprogressoflivercirhosis(RO.05).TheplateletlevelsatstagingIS1),stagingII(SII),stagingIII(SIII)andstagingIV(SIV)wereasthefollows:(166.2~31.9)X109/L,(147.4~34.0)X109/L,(113.8~30.
8、4)×10/L,(89.9±19.0)×109/L,showingsignificantdifference(0.01).TheMPVWasenlargedwiththeprogressofseverityofhepaticfibrosis.WhilePDWshowedsignificantdifferenceatSI(9.1±1.3,9.4~0.8)andSIVstaging,(9.8-+0.9,10.1±O.
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