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时间:2020-05-07
《兰州地区慢性乙型肝炎患者病毒复制与肝纤维化指标的相关性研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、国际检验医学杂志2014年7月第35卷第14期lntJLabMed,July2014,Vo1.35,No.14·临床检验研究论著·兰州地区慢性乙型肝炎患者病毒复制与肝纤维化指标的相关性研究吴斌,李彩东,段正军,田鹏飞,李惠军(甘肃省兰州市第二人民医院肝病研究所,甘肃兰州730046)摘要:目的探讨兰州地区慢性乙型肝炎(CHB)患者肝纤维化四项指标:层粘连蛋白(LN)、透明质酸(HA)、Ⅳ型胶原(ClV)、1I型前胶原N端肽(PllINP)与乙型肝炎病毒(HBV)DNA复制的相关性。方法分别采用化学发光法和实时荧光
2、定量PCR(RT—PCR)法检测肝纤维化指标和HBv_DNA,以不同临床分型和自然史分期为背景,对兰州地区724例HBV感染者的肝纤维化指标和病毒复制作量化检测研究。结果在所有临床类型中,肝纤维化指标和HBV-DNA数值均高于正常,且最高为乙型肝炎肝硬化组;CIV、P1]INP均以HBeAg(+)CHB组最高。按乙型肝炎自然史分期,PI1NP、CIV在免疫清除期最高且CIV在HBeAg及HBV—DNA(+)组中均值都高于HBeAg及HBV—DNA(一)组。四项指标均为HBeAg(+)CHB组高于HBeAg(一)C
3、HB组,但仅有HA有统计学差异(P4、hronichepatitisBinLanzhouw“Bin,LiCaidong,DuanZhengJun,TianPengfei,LHuijun(LiverDiseasesResearchInstitute,LanzhouMunicipalSecondPeoplesHospital,Lanzhou,Gansu730046,China)Abstract:0hjectiveToinvestigatethecorrelationbetweentheliverfibrosismarkerslaminin(IN),hya5、luronanacid(HA),col—lagenIV(CⅣ)andprocollagentypeⅢN—terminalpeptide(P1INP)withthereplicationofhepatitisBvirus(HBV)DNAinthepatientswithchronicHBVinLanzhou.MethodsReal-timePCRandchemiluminescentimmunoassay(CIIA)wereusedtoquantita~tivelymeasureserumHBv_DNAandIiv6、erfibrosismarkersin724casesofHBVinfectioninLanzhouwiththedifferentclinicalclassificationsandthenaturalhistorystageasthebackground.ResultsThevaluesoftheliverfibrosisindicatorsandHBV—DNAlevelinallclinicaltypeswerehigherthannormallevels,andreachedtomaximuminthel7、ivercirrhosisgoup;CIVandPIIINpwerehighestintheHBeAg(+)CHBgroup;accordingtothehepatitisBnaturalhistorystage,thePllINPandCIVvaluesreachedthepeakvalueintheimmuneclearancephase,moreovertheCⅣmeanvalueintheHBeAgandHBV—DNA(+)groupwashigherthanthatintheHBv_DNAandHBeA8、g(一)group.4indicatorsintheHBeAg(+)CHBgroupwerehigherthanthoseintheHBeAg(一)CHBgroup,butonlyHAhadstatisticaldifference(P
4、hronichepatitisBinLanzhouw“Bin,LiCaidong,DuanZhengJun,TianPengfei,LHuijun(LiverDiseasesResearchInstitute,LanzhouMunicipalSecondPeoplesHospital,Lanzhou,Gansu730046,China)Abstract:0hjectiveToinvestigatethecorrelationbetweentheliverfibrosismarkerslaminin(IN),hya
5、luronanacid(HA),col—lagenIV(CⅣ)andprocollagentypeⅢN—terminalpeptide(P1INP)withthereplicationofhepatitisBvirus(HBV)DNAinthepatientswithchronicHBVinLanzhou.MethodsReal-timePCRandchemiluminescentimmunoassay(CIIA)wereusedtoquantita~tivelymeasureserumHBv_DNAandIiv
6、erfibrosismarkersin724casesofHBVinfectioninLanzhouwiththedifferentclinicalclassificationsandthenaturalhistorystageasthebackground.ResultsThevaluesoftheliverfibrosisindicatorsandHBV—DNAlevelinallclinicaltypeswerehigherthannormallevels,andreachedtomaximuminthel
7、ivercirrhosisgoup;CIVandPIIINpwerehighestintheHBeAg(+)CHBgroup;accordingtothehepatitisBnaturalhistorystage,thePllINPandCIVvaluesreachedthepeakvalueintheimmuneclearancephase,moreovertheCⅣmeanvalueintheHBeAgandHBV—DNA(+)groupwashigherthanthatintheHBv_DNAandHBeA
8、g(一)group.4indicatorsintheHBeAg(+)CHBgroupwerehigherthanthoseintheHBeAg(一)CHBgroup,butonlyHAhadstatisticaldifference(P
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