原发性肝癌腹水患者肾功能早期损害标志物的评价及意义-论文.pdf

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1、海南医学2014年3月第25卷第5期HainanMedJ，Mar．2014，Vo1．25，No．5doi：10．3969／j．issn．1003—6350．2014．05．0265原发性肝癌腹水患者肾功能早期损害标志物的评价及意义钟文洲，郑秀芳，李春芸(海口市人民医院消化内科、检验科，海南海口570208)【摘要】目的探讨原发性肝癌腹水患者肾功能早期损害标志物的评价及意义。方法选择我院收治的150例原发性肝癌患者，根据是否并发腹水分为肝癌组53例，肝癌腹水组97例，同期健康体检者38例作为正常对照组，检测静脉血和尿标本中的肾功能标志

2、物。结果肝癌腹水组和肝癌组血清CysC、IgG、mAlb、．一M、：一MG及SCr水平均明显高于对照组(JP

3、：一MG水平随着肝癌患者病情进展和肾功能损害而升高，比传统的血清SCr、Urea更敏感地反映肝癌腹水患者肾功能早期损害。【关键词】原发性肝癌；肾功能；标志物【中图分类号】R735．7【文献标识码】A【文章编号】1o03—635O(2014)O5—O682—03Evaluationandsignificanceofearlymarkersofrenalfunctiondamageinprimarylivercancerpatientswithascites．ZHONGWen-zhou，ZHENGXiu-fang，LIChun-yun2

4、．DepartmentofGastroenterology，DepartmentofClinicalLaboratory2PeopleHospitalofHaikouCity,Haikou570208,Hainan,CHINA【Abstract】ObjectiveToinvestigatetheevaluationandsignificanceofearlymarkersofrenalfunctiondam—ageinp．,~warylivercancerpatientswithascites，MethodsOnehundredan

5、dfiftypatientswithprimarylivercancerinourhospimlwereselected，anddividedintoliverCancergroup(n=53)andlivercancerascitesgroup(n=97)accord-ingtowhethertheywerecomplicatedwidaascitesThirty-eighthealthyindividualsoverthesameperiodwereselectedasthecontrolgroup．Markersofrenal

6、functioninbloodandurinespecimensweretested．ResultsThelevelsofCysC，IgG，mAlb，al—M，JB2-MGandSCrinlivercancergroupandlivercancerascitesgroupweresignificantlyhigherthanthoseinthecontrolgroup(尸l

7、lyhigherthanlivercancergroup(P<0．05)；CysC，IgG，mAlb，oft—Mand卢2一MGinlivercancergroupandlivercancerascitesgroupofChild-PughB，CweresignificantlyhigherthanChild-PughA(P<0．05)；CysC，IgG，mAlb，广M，2一MG，SCrandUreainlivercancerascitesgroupofChild-PughCweresignificantlyhigherthanCh

8、ild-PughB(P<0．05)．ConclusionCysC，IgG，mAlb，otl—Mandfl2一MGlevelsincreasewiththeprogressionofliv-ercancerandrenaldysfunc