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《安徽省某医院多重耐药革兰阴性菌流行情况及耐药分析-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·252·皖南医学院学报(JofWannanMedicalCollege)2014;33(3·临床医学·文章编号:1002—0217(2014)03—0252—04安徽省某医院多重耐药革兰阴性菌流行情况及耐药分析朱红,喻艳林,侯为顺,杨剑,谢文斌(皖南医学院附属弋矶山医院感染性疾病科,安徽芜湖241001)【摘要】目的:了解2011—2013年我院临床分离多重耐药革兰阴性菌流行情况、耐药及变迁。方法:采用Vitek一32全自动微生物分析仪及纸片扩散法对分离菌进行鉴定及药敏实验。结果:3年期间临床分离多重耐药菌共1905株
2、,占分离病原菌的18.9%,其中革兰阴性菌占74.6%。分离出的多重耐药革兰阴性菌数依次为大肠埃希菌、肺炎克雷伯菌、醋酸钙鲍曼复合不动杆菌、铜绿假单胞菌。多重耐药大肠埃希菌、肺炎克雷伯菌对碳青霉烯类3年内均保持极低的耐药率,对头孢哌酮/舒巴坦虽保持高的敏感性,但耐药率呈增高趋势。多重耐药铜绿假单胞菌、鲍曼复合不动杆菌耐药率高,对常用抗生素耐药率多在50%以上,部分为泛耐药株。结论:多重耐药菌对常用抗菌药物耐药状况严重,需加强抗感染管理制度执行和多重耐药菌的监测,并根据药敏试验结果合理应用抗菌药物。【关键词】细菌药敏试验;
3、多重耐药菌;多重耐药革兰阴性细菌;耐药性;合理用药【中图号】R446.5【文献标识码】A【DOI】10.3969/j.issn.1002-0217.2014.03.021Epidemiologicalcharacteristicsofmultidrug·-resistantgram--negativebacteriainahospitalinAnhuiprovinceanddrugresistanceanalysisZHUHong,YUYanlin,HOUWe~hun,YANGJian,XIEWenbinDepartme
4、ntofInfectiousDiseases,YijishanHospital,WannanMedicalCollege,Wuhu241001,China【Abstract】Objective:Tounde~tandepidemiologicalcharacteristics,drugresistanceandchangingtendencyofmuhidrug-resistantgram—negativebacteriaisolatedinourhospitalduringtheperiodof2011—2013.Me
5、thods:Vitek-32automaticmicrobialanalyzerwasusedtoidentifythebacteriaisolatedanddiscdiffusionmethodforexaminingthedrugsusceptibility.Results:Ina3一yearperiod,atotalof1905muhidrug—resistantbacteriastrainswereidentified,whichaccountedfor18.9%ofthepathogenicbacteria.a
6、nd74.6%weregram—negativebacteria.Theisolatedmuhidrug—resistantgram-negativebacteriaweresequentiallywithEscherichiacoli,Klebsiellapneumoniae,CalciumacetatecompositeacinetobacterbaumannandPseudomonasaeruginosa.EscherichiacoliandKlebsiellapneumoniaofmuhidrug—resista
7、nceremainedlowerdrugresistancerateforCarbapenemsin3years.AhhoughthebacteriamaintainedhighsensibilitytoCefoperazone-sulbactam,thedrugresistanceratetendedtoincrease.Higherresistancerateswerefoundformuhidrug—resistantPseudo—monasaeruginosaandAcinetobacterbaumannii.i
8、nwhichover50%wereresistanttoconventionalindividualantibiotics,andworseenough,someofthestrainswerepan-drugresistance.Conclusion:Resistancetoconventionalindividu
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