扶正抑瘤汤诱导肝癌HepG2细胞凋亡及自噬作用研究-论文.pdf

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1、102中药药理与临床2013；29(5)kg)bytheirbasalbodytemperature．Besidesblankcontrolgroup，the10％yeastsuspensionweresubcutaneousinjectedtoallothergroupsonlOml／kgd0seforindueefever．Intragastrieadministrationwereactedon6，8，10hoursforallgroupsafterfeverinduced．Thebodytempera-turewasmeasur

2、odeveryhourfor24hour．LPSinducedrabbitfeverexperiment：111eratsweredividedtoblankcontrolgroup，modelgroup，Daruqigroup(0．25g／kg)，ibuprofentabletsgroup(0．1g／kg)bytheirbasalbodytemperature．Besidesblankcontrolgroup，earveininjectionofLPSwereactedonallothergroupsondoseof0．75ug／kg

3、forinducefever．Intragastrieadministrationwasactedtoallgroupswhenfeverin—ducedand2hoursafterfever．Thebodytemperaturewasmeasuredeveryhourfor8hour．Calculatetheheatingvalueofallgroups；calculatethem~imumvalueoftemperatureresponseindexofheatingvalue：&awcurveofaveragetemperatur

4、e．Result：Themsultofdryyeastin。ducedratfeverexperimentshowedthatthebodytemperatureofDaruqilowdosegroupweredecreasedobviouslyon10—17hourand22～24hourafterfeverinduction．comparedwithblankcontrolgroup，nosignificantdiferences，P>0．05；thebodytemperatureweresignificantlylowerthan

5、modelgroup7～17hour，23～24hourafterfeverinduction，havesignitlcandydiferences，P<0．05；thebodytemperaturewereSignificantlylowerthanibuprofengroup16-17hour，19-24hourafterfeverinduction，havesignificantlydiferences，P<0．05．TheTRI16-13andTRI13～24ofDamqiparticlesgroupdecreasedsigni

6、ficantly，comparewithmodelgroup，havesignificantdiferences，P<0．05；theTRI13-24lowerthenibuprofengroup，hadsignificantdiferences，P<0．05；comparedwithblankcontrolgroup，nosignificantdiferences，P>0．05．ThebodytemperatureofDaruqihig}ldosegroupdecreasedat11—24hourafterfeverinduction

7、，havenosignificantdiferences，P>0．05；lowerthanmodelgroupat7—17hour，19—21hour，23hourafterfeverinduction，havesignificantdifferences，P<0．05；lowerthanibuprofengroupat16～24hour，hadsignificantdiferences，P<0．05．TRI6～13andTRI13～24ofDaruqihighdosegroupdecreasedsignificantly，compar

8、edwithmodelgroup，hadsignificantdiferences，P<0．05；TRI13～24significantlylowerthanibuprofengroup，hadsignif