资源描述：
《甲亢hyperthyroidism课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、HyperthyroidismIntroductionDefinition：FunctionofthyroidismmetabolismmanysystemsexcitabilityMostcommonisdiffusetoxicgoiter(Gravesdisease,GD),85%VariouscausesGravesdisease:85%Autonomoustoxicadenomasofthethyroid:Plummer'sdiseaseortoxicmultinodulargoiterJodbasedowdisease[,dʒɔd'ba:zidəu]Functioni
2、ngthyroidcarcinomaTSHhypersecretionbythepituitaryStrumaovariiSubacutethyroiditis[,sʌbə'kjuːt][,θaɪrɒɪ'daɪtɪs]Hashimoto'sthyroiditisThyrotoxicosisfactitiaθaɪrəʊ,tɒksɪ'kəʊsɪsCarcinomaaccompanyingthyrotoxicosis85%Maletofemale1:4-6ChiefclinicalfindingsGravesdiseaseSymptomsduetoHypermetabolismgoi
3、torOphthalmopathy[ɒf'θælməʊpəθɪAbnormalimmune:TRAbHeredityInfection:MolecularmimicryCytokineSuperantigenSpiritirritationEtiologyandPathophysiologyClinicalmanifestationCommonSymptomsduetoHypermetabolism:Heatintolerance,excessiveperspiration,warmmoistsmoothskin,fatigue,weightloss.Goitor:Enlarg
4、ementornodules['nɒdju:lz]['nɒdju:lz]Ophthalmopathy:Asenseofirritationineyes,excessivetearing,exophthalmos,blurredvision,easytiringoftheeyes,doublevision.图1图2图3图4Nervoussystem:Nervousness,emotionallability,irritability,finetremorofhands.Cardiovascular:Palpitation,tachycardia,atrialfibrillatio
5、n,widenedpulsepressure.Gastrointestinal:Increasedappetite,Hyperdefecation,diarrheaHematologicsystem:Moderateneutropenia,mildanemia.Others:Muscleatrophy.ClinicalmanifestationCommonClinicalmanifestationExceptiveT3Toxicosis:initialphasesorarelapseofGDT4ToxicosisApathetichyperthyroidismThyrotoxi
6、ccrisisThyrotoxicmyopathy:Hypokalemicperiodicparalysisetc.HyperthyroidisminpregnancyCardiaccomplications:atrialfibrillationLaboratoryDiagnosisSerumT3,T4,FT3,FT4SensitiveTSHassaySerumTRAbTestofTRHirritationRadioactiveiodineuotake:Normal:3h5-25%,24h20-45%,peakat24hThyroidscan:131I,99mTcDiagnos
7、isSymptomsSignsLaboratoryexaminationDifferentialdiagnosisOthercausesofthyrotoxicosisAnxietyneurosisormaniaSomestatesofhypermetabolismwithoutthyrotoxicosis:severeanemia,leukemia,etc.Cardiacdisease:atrialfibrillation,anginaPheochromocytomaOthercauses
