药物不良反应课件

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1、Theclinicalpharmacologyofneonat1CharacteristicofmedicinereactionCharacteristicofpharmacokineticsSignificanceofdrugmonitoringMedicationofbreastmilkfeedingneonatSpecialreactionofneonatalmedicineRationaladministrationofneonatalcommondisease2Definitionofneonatalbornpostnatal28ds3Characteristicofneonat

2、1.functionalunderdevelopmentoforgan,underdevelopmentofenzymaticsystem,slowdrugmetabolismandevacuation2．Variationofdrugmetabolismandevacuationvelocityaccordingtothebirthweight,fetalageandpostnataldays3．individualdifferenceamongthesickbabies4．FunctionweakenSo,dosage,dosingintervalandadministrationro

3、utewillbedifferent4DrugabsorptionandrouteofadministrationAdministrationbygastrointestinaltract(GI/GIT):gastricacidity,gastricemptyingtime,pathologicstatus(PS)Administrationbynongastrointestinaltract1.hypodermicinjection，intramuscularinjection:regionalflow,characteristicofmedicine2.intravenousinjec

4、tion：fast5Payattentiontoneonatalintravenousinjection①Administrationaccordingtospecifyvelocity②Tobringaboutconstitutionnecrosisbydrugeffusion③Tocausethrombophlebitisbyinjectingthesamebloodvesselrepeatedly→Injectionsiteshouldbechanged④Toavoidusinghypso-concentration6DrugdispositionDrugdistributetos

5、ysbybloodcirculationorganization,fat,pH;Liposolubility,molecularwieght,proteinbindingrate,barrier7CharacteristicofdrugdispositionofneonatMoretotalbodywaterandextracellularfluidvolumeLessfatmassLowdegreeofplasmaproteinbindingUnderdevelopmentofblood-brainbarrier8DrugmetabolismOrgan:liver;Accretionra

6、te:sizeofhepar,metaboliccapabilityofenzymaticsystemLiposolublesubstances:excretedbybindingwithglucuronateorsulfateAdeclineoftheaccretionrate:lowenzymaticactivityofglucuronyltransferaseofneonat9bindingwithglucuronate:indomethacin,salicylate,chloramphenicolChloramphenicolgraybabysyndromesulfoconjuga

7、tionglucuronateDrugmetabolism10DrugexcretionOrgan:kidneyUnderdevelopmentofNephridialtissue;Fewerglomcrulusglomerularfiltration＋tubularsecretionacid-basebalance＋water-electrolytemetabolismprimetype11Significanceof