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时间:2020-05-02
《右美托咪定在局部麻醉乳突根治术中的临床应用.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第34卷第6期武汉大学学报(医学版)Vo1.34No.62013年11月MedicalJournalofWuhanUniversityNov,2013右美托咪定在局部麻醉乳突根治术中的临床应用吴洋窦娟。夏中元王鄂友孟庆涛唐玲华吴磊。武汉大学人民医院麻醉科,心血管外科湖北武汉430060。武汉科技大学医学院公共卫生学院湖北武汉430065摘要目的:研究右美托咪定辅助局麻在乳突根治术中的镇静效果。方法:选择8O例欲行乳突根治术的患者,随机分为对照组(C组)和右美托咪定组(D组),每组各4O例,D组给予右美托咪定0.5~g/kg负荷量10min输注完毕,
2、继以0.5g/(kg·h)泵注维持至术毕,C组给予等容量生理盐水。观察并记录两组患者给药前(T。)、给药10min时(T)、给药60min(T2)和术毕时(T。)的平均动脉压(MAP)、心率(HR)、脉搏血氧饱和度(SPO)和OAA/S评分,观察有无呼吸抑制等不良反应的发生。结果:与c组相比,D组患者HR、MAP、0AA/s评分在rr】一T。时点明显低于C组患者,差异有显著性(P3、的术中镇静。关键词右美托咪定;乳突根治术;镇静中图分类号R971.2文献标识码A文章编号1671—8852(2013)06—0917-03ClinicalApplicationofDexmedetomidineasanAdjuncttoLocalAnesthesiainRadicalMastoidectomyWUYang,DOUJuan,XIAZhongyuan,WANGEyou,MENGQingtao,TANGLinghua。wULei。Dept.ofAnPs8s0Z0g,Dept.ofCardiovascularSurgery,RenminHo4、spitalofWuhanUniversity,Wuhan430060,China。SchoolofPublishHealth,WuhanUniversityofScienceandTechnology,Wuhan430065,ChinaAbstractObjective:ToevaluatethesedativeeffectofintravenousdexmedetomidineasanadjuncttolocaIanesthesiainradicalmastoidectomy.Methods:EightypatientsofASA工一Ⅱwhou5、nderwentselectiveoperationofradicalmastoidectomyunderloca1anesthesiawererandomlyassignedtOcontrolgroup(groupC)anddexmedetomidinegroup(groupD).Changesofheartrate(HR),meanarterialpressure(MAP),satiationofoxygen(SPO2)andtheObserverSAssessmentofAlertness/Sedationscale(0AA/s)wereme6、asuredbeforeanesthesia(T0),afterinjectionat10min(T1),6Omin(T2)andattheendofoperation(T3).Results:HR,MAP,andOAA/SscoreweredecreasedingroupDandthedecreaseoftheseindiceswasmuchmoresignificantingroupDthaningroupC(P%0.05).TherewasnosignificantchangeinSPOzbetweenthetwogroupsdur—ingt7、heoperation.Conclusion:Dexmedetomidinecanachievesatisfyingsedativeeffectanddisplayastablehemodynamicstatewithoutrespiratoryinhibition.Itcanbeusedforsedationinradical课题来源:国家自然科学基金资助项目(编号:81201458)作者简介:吴洋,男,I980一,医学博士,主治医师,主要从事麻醉与脏器保护的研究通讯作者:夏中元,男,1965一,医学博士,主任医师,博士生导师,主要从事围手术期脏8、器保护的研究918武汉大学学报(医学版)第34卷mastoidectomyunderlocalanesthesia.Key
3、的术中镇静。关键词右美托咪定;乳突根治术;镇静中图分类号R971.2文献标识码A文章编号1671—8852(2013)06—0917-03ClinicalApplicationofDexmedetomidineasanAdjuncttoLocalAnesthesiainRadicalMastoidectomyWUYang,DOUJuan,XIAZhongyuan,WANGEyou,MENGQingtao,TANGLinghua。wULei。Dept.ofAnPs8s0Z0g,Dept.ofCardiovascularSurgery,RenminHo
4、spitalofWuhanUniversity,Wuhan430060,China。SchoolofPublishHealth,WuhanUniversityofScienceandTechnology,Wuhan430065,ChinaAbstractObjective:ToevaluatethesedativeeffectofintravenousdexmedetomidineasanadjuncttolocaIanesthesiainradicalmastoidectomy.Methods:EightypatientsofASA工一Ⅱwhou
5、nderwentselectiveoperationofradicalmastoidectomyunderloca1anesthesiawererandomlyassignedtOcontrolgroup(groupC)anddexmedetomidinegroup(groupD).Changesofheartrate(HR),meanarterialpressure(MAP),satiationofoxygen(SPO2)andtheObserverSAssessmentofAlertness/Sedationscale(0AA/s)wereme
6、asuredbeforeanesthesia(T0),afterinjectionat10min(T1),6Omin(T2)andattheendofoperation(T3).Results:HR,MAP,andOAA/SscoreweredecreasedingroupDandthedecreaseoftheseindiceswasmuchmoresignificantingroupDthaningroupC(P%0.05).TherewasnosignificantchangeinSPOzbetweenthetwogroupsdur—ingt
7、heoperation.Conclusion:Dexmedetomidinecanachievesatisfyingsedativeeffectanddisplayastablehemodynamicstatewithoutrespiratoryinhibition.Itcanbeusedforsedationinradical课题来源:国家自然科学基金资助项目(编号:81201458)作者简介:吴洋,男,I980一,医学博士,主治医师,主要从事麻醉与脏器保护的研究通讯作者:夏中元,男,1965一,医学博士,主任医师,博士生导师,主要从事围手术期脏
8、器保护的研究918武汉大学学报(医学版)第34卷mastoidectomyunderlocalanesthesia.Key
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