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时间:2020-05-02
《右美托咪定用于高龄患者腹腔镜胆囊切除术全麻维持的临床研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、临床麻醉学杂志2014年6月第3O卷第6期JClinAnesthesiol,June2014,V0【
2、30,No.6.临床研究.右美托咪定用于高龄患者腹腔镜胆囊切除术全麻维持的临床研究颜景佳王阵英刘西将赵桀江长城【摘要】目的探讨右美托咪定代替丙泊酚镇静用于高龄患者腹腔镜胆囊切除术(LC)中麻醉维持的可行性。方法选择择期行LC的70岁以上高龄患者90例,随机分为丙泊酚+瑞芬太尼麻醉维持组(A组)和右美托咪定+瑞芬太尼麻醉维持组(B组),每组45例。A组患者诱导前不给药,B组患者给予0.5“g/kg负荷剂量的右美托咪定静脉注射
3、,在10min内静注完毕。两组患者麻醉诱导方法相同,诱导后均经口插入3或4喉罩。麻醉维持:A组以丙泊酚2.O~3.0t~g/ml+瑞芬太尼4.5~5.5ng/ml静脉TCI维持麻醉;B组在麻醉诱导后则以右美托咪定0.25g·kg_1·h4-瑞芬太尼4.5~5.5ng/ml静脉TCI。观察插入喉罩时(T)、手术开始进镜时(Tz)、游离胆囊时(T3)、撤镜时(T4)、拔除喉罩Et~(T)的HR、SBP、DBP、BIS值。观察两组患者术后的苏醒时间和拔除喉罩时的Steward苏醒评分和改良()AA/S评级。结果不同时点两组BIS
4、比较差异无统计学意义。与A组比较,T~T时B组HR明显减慢,SBP、DBP明显降低(P5、rgen—eralanesthesiaYANJing-jia。WANGZhen—ying,L,U尉一jiang,ZHAOJie,HANGChang-cheng.DepartmentAnesthesiology,FirstAffiliatedQuanzhouHospitalofFujianMedicalUniversity,Quanzhou362000,ChinaCorrespondingauthor:YANJing-jia,Email:qzyyyjj@126.com[Abstract]ObjectiveReplacemen6、tofdexmedetomidinewithpropofolformaintainingtheanes—thesiainelderlypatientsundergoinglaparoscopiceholecystectomy.MethodsNinetypatients,over7Oyearsold.undergoinglaparoscopiccholecystectomywererandomlydividedinto2groups,propofolcombinedwithremifentani1(groupA),dexme7、detomidinecombinedwithremifentanil(groupB),45patientsineachgroup.GroupAwasnottreatedwithanypreoperativemedication,whilegroupBwastreatedwithloadingdoseof0.5gg/kgdexmedetomidineintravenouslycompletedwithin10minutes.Inductionmethodsweresameinbothgroups。3or4#laryngeal8、maskwereinsertedafterinductioninbothgroups.MaintenanceofanesthesiaingroupAtreatedwithpropofol2.0-3.0/,g/ml4-4.5-5.5ng/mlTCI;MaintenanceofanesthesiaingroupBtreatedwithdexmedetomidine0.25g·kg一·h+remifentani14.5-5.5ng/ml(TCI).HR,SBP,DBP,BISwererecordedatinsertingtheL9、MA(T1),beginningofthesurgery(T2),dissociatethecholecyst(]r3),withdrawalofthelaparoscope(T4),extubatetheLMA(Ts).Postoperativerecoverytime,Stewardawakenin
5、rgen—eralanesthesiaYANJing-jia。WANGZhen—ying,L,U尉一jiang,ZHAOJie,HANGChang-cheng.DepartmentAnesthesiology,FirstAffiliatedQuanzhouHospitalofFujianMedicalUniversity,Quanzhou362000,ChinaCorrespondingauthor:YANJing-jia,Email:qzyyyjj@126.com[Abstract]ObjectiveReplacemen
6、tofdexmedetomidinewithpropofolformaintainingtheanes—thesiainelderlypatientsundergoinglaparoscopiceholecystectomy.MethodsNinetypatients,over7Oyearsold.undergoinglaparoscopiccholecystectomywererandomlydividedinto2groups,propofolcombinedwithremifentani1(groupA),dexme
7、detomidinecombinedwithremifentanil(groupB),45patientsineachgroup.GroupAwasnottreatedwithanypreoperativemedication,whilegroupBwastreatedwithloadingdoseof0.5gg/kgdexmedetomidineintravenouslycompletedwithin10minutes.Inductionmethodsweresameinbothgroups。3or4#laryngeal
8、maskwereinsertedafterinductioninbothgroups.MaintenanceofanesthesiaingroupAtreatedwithpropofol2.0-3.0/,g/ml4-4.5-5.5ng/mlTCI;MaintenanceofanesthesiaingroupBtreatedwithdexmedetomidine0.25g·kg一·h+remifentani14.5-5.5ng/ml(TCI).HR,SBP,DBP,BISwererecordedatinsertingtheL
9、MA(T1),beginningofthesurgery(T2),dissociatethecholecyst(]r3),withdrawalofthelaparoscope(T4),extubatetheLMA(Ts).Postoperativerecoverytime,Stewardawakenin
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