低分子肝素钙联合灯盏花素治疗对老年肺源性心脏病急性发作期 NO、ET-1水平的影响.pdf

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1、国际检验医学杂志2014年7月第35卷第13期IntJLabMed，July2014，Vo1．35，No．13·临床检验研究论著·低分子肝素钙联合灯盏花素治疗对老年肺源性心脏病急性发作期NO、ET一1水平的影响钟伟，廖雪梅，李章白△(重庆市荣昌县人民医院内三科402460)摘要：目的探讨低分子肝素钙联合灯盏花素对老年慢性肺源性心脏病(简称肺心痛)急性发作期的治疗效果及发病机制。方法将2011年1O月至2013年6月在本院住院的共86例确诊的老年肺心痛患者随机分为两组，两组患者年龄、性别、病情无显著差异，其中治疗组44例，对照组42例。两组均给予

2、常规治疗，治疗组在常规治疗基础上加用低分子肝素钙和灯盏花素。观察两组患者治疗后临床症状改善及NO、ET一1水平的改变情况。结果两组患者临床疗效总有效率分别为9o．1和71．4；两组患者N0、ET一1水平均有明显改善，治疗组疗效优于对照组，差异有统计学意义(P

3、文章编号：1673—4130(2014)13—1691-03EffectsoflowmolecularweightheparincalciumcombinedwithbreviscapinionplasmaNOandET-1inacuteexacerbationofelderlychronicpulmonaryheartdiseaseZhongWei，LiaoXuemei，LiZhangbai(DepartmentofInternalMedicine，RongchangCountyPeoplesHospital，Chongqing402460，

4、China)Abstract：ObjectiveToinvestigatetheeffectoflowmolecularweightheparincalciumcombinedwithbreviscapiniintreatinga—cuteexacerbationofelderlychronicpulmonaryheartdiseaseanditsmechanism．Methods86patientswithacuteexacerbationofelderlychronicpulmonaryheartdiseaseinourhospitalfr

5、omOctober2011toJune2013wererandomlydividedintotwogroups．Therewerenosignificantdifferencesinage，genderanddiseaseconditionbetweenthetwogroups．44caseswereinthetherapygroupandtheother42caseswereinthecontrolgroup．Bothtwogroupsreceivedtheroutinetherepy．Onthisbasisthetherapygroupwa

6、saddedwithlowmolecularweightheparincalciumandbreviscapini．Thentheimprovementofclinicalsymptomsandthechangesofplasmanitricoxide(NO)andendothelin一1(ET-1)aftertreatmentwereobservedinthetwogroups．ResultsThetotaleffectiveratesinthetherapygroupandthecontrolgroupwere90．1and71．4resp

7、ectively；thelevelsofplasmaNOandET一1aftertreatmentinthetwogroupsweresignificantlyimproved，buttheimprovementinthetherapygroupwasbetterthanthatinthecontrolgroupwiththestatisticaldifferencebetweenthem(P~O．05)．ConclusionLowmolecularweightheparincalciumcombinedwithbreviscapinicans

8、ignificantlyimprovethesymptomsintheederlypulmonaryheartdisease，decreasethel