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时间:2020-05-02
《呼气末正压通气对不同体质量指数阻塞性睡眠呼吸暂停患者全麻术中呼吸功能的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国医师杂志—20l3年12月第15卷第12期JournalofChinesePhysician,December2013,Vo1.15.No.12·论著·呼气末正压通气对不同体质量指数阻塞性睡眠呼吸暂停患者全麻术中呼吸功能的影响刘炜炜裴凌【摘要】目的分析呼气末正压(PEEP)通气对不同体质量指数(BMI)阻塞性睡眠呼吸暂停(OSA)患者全麻术中呼吸功能的影响。方法观察组:择期行悬雍垂腭咽成形术的OSA患者4O例,按照BMI将患者分为2组(n=20):A组,26ks/m2、>32ks/m。对照组(C组):择期行鼓室成形术患者20例,BMI<24kg/m。所有病例性别不限,年龄20—57岁,ASAI或Ⅱ级。麻醉诱导前面罩吸入纯氧10min。常规诱导,经口气管插管,机械通气。3组病例均在诱导后先后使用0cmHOPEEP和8cmH2OPEEP各通气60min。监测动态呼出末二氧化碳(PCO2)、气道峰压(P)、胸肺顺应性(c)、气道阻力(R)和动态压力一容积(P-V)曲线。分别于诱导后5min(T。)、60min(T2)、120min(Ts)记录PErCO:、CR,观察P—V曲线3、变化。于清醒状态未吸氧前(To)、T一L采集动脉血样行血气分析。计算氧合指数(PaO:/FiO:)、呼吸指数(RI)和生理无效腔(VD/VT)。结果与T0时比较,B组于T和T2时PaO2/FiO2下降,RI升高(P<0.05)。与T。时比较,B组于T3时PaO:/FiO、C升高,RI下降(P<0.05)。与c组比较,B组于T。和T:时PaO2/FiO2和c降低(P<0.05);于Tl—L时R、RI、VD/VT升高(P<0.05)。术中及术后24h,3组病例血流动力学稳定,无不良反应发生。结论全麻状态下,O4、SA肥胖患者会出现更严重的呼吸功能改变,术中应用PEEP有助于改善气体交换和呼吸力学指标,对血流动力学无明显影响。[关键词]正压呼吸;人体质量指数;睡眠呼吸暂停,阻塞性/外科学;麻醉,全身;呼吸Effectsofpositiveend-expiratorypressureonrespiratoryfunctionofthepatientsofobstructivesleepapneawithdiferentbodymassindexduringgeneralanesthesiaLIUWei—wei.PEI5、Ling.DepartmentofAnesthesiology,FirstHospitalofChinaMedicalUniversity,Shenyang110001,ChinaCorrespondingauthor:PEILing.Email:lingpei49@vip.sina.con【Abstract】ObjectiveToanalyzetheeffectsofpositiveend—expiratorypressure(PEEP)onrespir—atoryfunctionofthepatien6、tsofobstructivesleepapnea(OSA)withdifferentbodymassindexduringgener—alanesthesia.MethodsFonypatientsundergoingelectiveuvulopalatopharyngoplastyweredividedintotwobodyweightgroups(n=20each);groupAoverweightpatiens(26ks/7、>32ks/m).Controlgroup:twentypatientswithBMI<24kg/mscheduledfore—lectivetympanoplasty.AllthepatientswereofASAgradeIorII.aged20~57years.Beforeinductionofanesthesia,preoxygenationwasgivenduring10minbyusing100%02withasealmask.Afterinductionofanesthesiaasusual8、,thepatientswereintubatedwithanorotrachealtubeandmechanicallyventilated.Allpatientsofthreegroupswereapplied0cmOPEEPandthen8cmH2OPEEP,andmaintainedfor60mineach.Duringtheprocedure,end—tidalcarbondioxidepressure(PETCO2
2、>32ks/m。对照组(C组):择期行鼓室成形术患者20例,BMI<24kg/m。所有病例性别不限,年龄20—57岁,ASAI或Ⅱ级。麻醉诱导前面罩吸入纯氧10min。常规诱导,经口气管插管,机械通气。3组病例均在诱导后先后使用0cmHOPEEP和8cmH2OPEEP各通气60min。监测动态呼出末二氧化碳(PCO2)、气道峰压(P)、胸肺顺应性(c)、气道阻力(R)和动态压力一容积(P-V)曲线。分别于诱导后5min(T。)、60min(T2)、120min(Ts)记录PErCO:、CR,观察P—V曲线
3、变化。于清醒状态未吸氧前(To)、T一L采集动脉血样行血气分析。计算氧合指数(PaO:/FiO:)、呼吸指数(RI)和生理无效腔(VD/VT)。结果与T0时比较,B组于T和T2时PaO2/FiO2下降,RI升高(P<0.05)。与T。时比较,B组于T3时PaO:/FiO、C升高,RI下降(P<0.05)。与c组比较,B组于T。和T:时PaO2/FiO2和c降低(P<0.05);于Tl—L时R、RI、VD/VT升高(P<0.05)。术中及术后24h,3组病例血流动力学稳定,无不良反应发生。结论全麻状态下,O
4、SA肥胖患者会出现更严重的呼吸功能改变,术中应用PEEP有助于改善气体交换和呼吸力学指标,对血流动力学无明显影响。[关键词]正压呼吸;人体质量指数;睡眠呼吸暂停,阻塞性/外科学;麻醉,全身;呼吸Effectsofpositiveend-expiratorypressureonrespiratoryfunctionofthepatientsofobstructivesleepapneawithdiferentbodymassindexduringgeneralanesthesiaLIUWei—wei.PEI
5、Ling.DepartmentofAnesthesiology,FirstHospitalofChinaMedicalUniversity,Shenyang110001,ChinaCorrespondingauthor:PEILing.Email:lingpei49@vip.sina.con【Abstract】ObjectiveToanalyzetheeffectsofpositiveend—expiratorypressure(PEEP)onrespir—atoryfunctionofthepatien
6、tsofobstructivesleepapnea(OSA)withdifferentbodymassindexduringgener—alanesthesia.MethodsFonypatientsundergoingelectiveuvulopalatopharyngoplastyweredividedintotwobodyweightgroups(n=20each);groupAoverweightpatiens(26ks/7、>32ks/m).Controlgroup:twentypatientswithBMI<24kg/mscheduledfore—lectivetympanoplasty.AllthepatientswereofASAgradeIorII.aged20~57years.Beforeinductionofanesthesia,preoxygenationwasgivenduring10minbyusing100%02withasealmask.Afterinductionofanesthesiaasusual8、,thepatientswereintubatedwithanorotrachealtubeandmechanicallyventilated.Allpatientsofthreegroupswereapplied0cmOPEEPandthen8cmH2OPEEP,andmaintainedfor60mineach.Duringtheprocedure,end—tidalcarbondioxidepressure(PETCO2
7、>32ks/m).Controlgroup:twentypatientswithBMI<24kg/mscheduledfore—lectivetympanoplasty.AllthepatientswereofASAgradeIorII.aged20~57years.Beforeinductionofanesthesia,preoxygenationwasgivenduring10minbyusing100%02withasealmask.Afterinductionofanesthesiaasusual
8、,thepatientswereintubatedwithanorotrachealtubeandmechanicallyventilated.Allpatientsofthreegroupswereapplied0cmOPEEPandthen8cmH2OPEEP,andmaintainedfor60mineach.Duringtheprocedure,end—tidalcarbondioxidepressure(PETCO2
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