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1、中国组织工程研究与临床康复第15卷第50期2011–12–10出版JournalofClinicalRehabilitativeTissueEngineeringResearchDecember10,2011Vol.15,No.50兔桡骨临界骨缺损模型的制备*☆◆11222周芳，李静，余磊，廖华，欧阳钧Establishmentofaradialbonecriticaldefectmodelinarabbit11222ZhouFang,LiJing,YuLei,LiaoHua,OuyangJunAbstract1BACKGROUND:Nonunio
2、ncausedbyvariousreasonsoffracturesandbonedefectshasbeenamajorproblemofclinicalSouthernMedicalorthopedicrehabilitation.Withtherapiddevelopmentoftissueengineering,productqualitytestingneedsstandardbonedefectUniversity,Guangzhoumodel.However,thelengthofbonecritical-sizedefectshas
3、notbeenascertained.510515,GuangdongOBJECTIVE:Toestablishrabbitradialbonedefectmodelsandtodeterminethelengthofrabbitradialbonecritical-sizedefects.Province,China;2METHODS:EighteenmaleNewZealandwhiterabbits(2.0-2.5kg)wererandomlyassignedinto6groupsandthen12,13,14,15,Departmentof
4、16and17mmsegmentaldefectswerecreatedinthemiddlepartofradiusonbothsides,respectively.TheincisionswereHumanAnatomy,SouthernMedicalsuturedandbandaged,butnotfixed.University,RESULTSANDCONCLUSION:AccordingtoexaminationwithnakedeyesandX-ray,someofthesegmentaldefectswiththeGuangdongl
5、engthof12,13,14,15and16mmwerecompletelyrepaired.Butnoneofthedefectswiththelengthof17mmwasrepaired.ProvincialKeyHistologicalexaminationshowedthattherewastrabecularboneformation,bonematrix,medullarycavityrecanalization,LaboratoryofTissueConstructionandrevascularizationandosteobl
6、astsinthesegmentaldefectswiththelengthof12,13,14,15and16mm.However,therewereInspection,osteoblasts,osteoclastsinthe17mmdefects,butnomedullarycavityrecanalizationorrevascularization.Therefore,thelengthGuangzhou510515,ofbonecritical-sizedefectinrabbitradiuswas17mm.GuangdongProvi
7、nce,ChinaZhouF,LiJ,YuL,LiaoH,OuyangJ.Establishmentofaradialbonecriticaldefectmodelinarabbit.ZhongguoZuzhiGongchengZhouFang☆,YanjiuyuLinchuangKangfu.2011;15(50):9385-9388.[http://www.crter.cnhttp://en.zglckf.com]Studyingfordoctorate,SouthernMedicalUniversity,摘要Guangzhou510515,G
8、uangdongProvince,背景：各种原因造成的骨折和骨缺损导致的骨不连一直是临床骨科修复的一大难题，相关产品质量的
