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ID:36566541
大小:3.46 MB
页数:64页
时间:2019-05-12
《复合型异种骨修复兔桡骨缺损的实验研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、山西医科大学硕士学位论文复合型异种骨修复兔桡骨缺损的实验研究姓名:陈斌申请学位级别:硕士专业:骨外科学指导教师:卢汉生2003.5.20竺!苎兰苎竺!主竺竺!竺苎——————————————————L—一cPCBPCBBMPaFGFbFGFPDGFTGF—BIGFVEGFPLAPGAHATCP文中所用英文缩略词索引compositeporcinecancellousboneporcinecancellousbonemorphogenicproteinacidicfibroblastbasicfibroblastDletetransletderivedformi
2、nggrowgrowthfactorgrowthfactorgrowthfactorthfactorinsulin—likegrowthvascularendothelialp01ylacticacidpoly91ycolicacidhydroxyapatitetricalciumphosphatefactorgrowthfactor坐耍匿型盔兰—————上生竺型塑垒兰——三—一复合型异种骨修复兔桡骨缺损的实验研究研究生陈斌导师卢汉生【文摘】目的用骨生长多肽,I型胶原与去抗原松质骨复合,观察复合骨的成骨效果。方法手术造成兔子双侧桡骨15mm长缺损,分别植入去抗
3、原猪松质骨,自体骨,复合骨。术后当时及2、4、8、12、16周,进行放射学检查,并测定缺损部位的灰度值,进行放射计量分析。4、8、12、16周处死动物,取标本进行组织学及组织计量分析。结果观察期内,复合骨组形成骨性连接,修复了缺损。灰度值比较,在8、12、16周明显高于单纯松质骨组(P4、各个时期均存在显著性差别。自体骨组在8周时发生骨性连接,修复了缺损。结论复合骨具有骨诱导活性,可以修复骨缺损。【关键词】异种臂移植胶原骨生长多肽些堕垦型叁兰一堡圭兰堡望垒兰——三——一ExperimentalStudyontheRepairofRadialDefectsinRabbitsTreatedwithcPCB(CompositePorcineCancel10usBone)Graduatestudent:BinChenTutor:HanshengLu.【Abstract】ObjectiveThisexperimentalstudywasaimtoinve5、stigatet11eef凳ctofosteogenesisofcPCB(compositeporcinecallcellousbone)whichweremadef.romPCB(porcinecanceHousbonelcombinedwithconcentrationofBoneExtractgro、VthpoIypepotideandtype-Icollagen.MethordsTwolatemlradialdefects,15millimeterslong,werecreatedinfo啊skeletallymatureNewZealandWhite6、Rabbits.Autogenouscorticalbone,pCB,andcPCBwereimplantedintothedefectsrespectiVely.RadiojFaphsofthedefectsweretakenatimmediate,2,4,8,12,16weekspostoperatiVely.TheValuesofgrayscaleofthedefectsweremeasurredwimRadiomo印hometry.At4,8,12,16weekspostoeratiVely;theanimalswerekilled,andbonefo7、rmationwereexaminedhistologicallyandhistomo印hometrically些堕堕型叁兰——————』生生兰竺兰苎——三—一Re蛐ltsBonyunionfbmed,anddefectswererepairedingroupofcPCBwithinobseⅣationalperiod.At8,12,16weeks,thedataofgrayscaleindefectsofcPcBweresigIlificalltlyhi曲erthantha_tofcPCBgmup.IngroupofcPCB:woVenboneoccun-e8、dat4weekspostoperat
4、各个时期均存在显著性差别。自体骨组在8周时发生骨性连接,修复了缺损。结论复合骨具有骨诱导活性,可以修复骨缺损。【关键词】异种臂移植胶原骨生长多肽些堕垦型叁兰一堡圭兰堡望垒兰——三——一ExperimentalStudyontheRepairofRadialDefectsinRabbitsTreatedwithcPCB(CompositePorcineCancel10usBone)Graduatestudent:BinChenTutor:HanshengLu.【Abstract】ObjectiveThisexperimentalstudywasaimtoinve
5、stigatet11eef凳ctofosteogenesisofcPCB(compositeporcinecallcellousbone)whichweremadef.romPCB(porcinecanceHousbonelcombinedwithconcentrationofBoneExtractgro、VthpoIypepotideandtype-Icollagen.MethordsTwolatemlradialdefects,15millimeterslong,werecreatedinfo啊skeletallymatureNewZealandWhite
6、Rabbits.Autogenouscorticalbone,pCB,andcPCBwereimplantedintothedefectsrespectiVely.RadiojFaphsofthedefectsweretakenatimmediate,2,4,8,12,16weekspostoperatiVely.TheValuesofgrayscaleofthedefectsweremeasurredwimRadiomo印hometry.At4,8,12,16weekspostoeratiVely;theanimalswerekilled,andbonefo
7、rmationwereexaminedhistologicallyandhistomo印hometrically些堕堕型叁兰——————』生生兰竺兰苎——三—一Re蛐ltsBonyunionfbmed,anddefectswererepairedingroupofcPCBwithinobseⅣationalperiod.At8,12,16weeks,thedataofgrayscaleindefectsofcPcBweresigIlificalltlyhi曲erthantha_tofcPCBgmup.IngroupofcPCB:woVenboneoccun-e
8、dat4weekspostoperat
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