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1、丹叶胶囊联合拉米夫定与阿德福韦酯治疗乙肝肝硬化代偿期的研究［摘要］目的观察丹叶胶囊治疗乙肝肝硬化代偿期的疗效。方法选择乙肝肝硬化代偿期患者60例，随机分为两组各30例。对照组采用常规保肝+拉米夫定+阿德福韦酯抗病毒治疗，治疗组在上述治疗的基础上加用丹叶胶囊治疗，观察治疗后两组患者肝功能(ALT复常率).HBV-DNA阴转率、肝纤维化血清指标(HA、LN、P-III-P、IV-C)和肝血流动力学变化。结果两组均有一定疗效，但治疗组总体疗效明显优丁对照组，差界有统计学意义(P〈0・01)；治疗组治疗后肝纤
2、维化血清标志物HA、LN、P-III-P、IV-C含量均较治疗前明显下降，且显著优于对照组(P〈0.01)；彩色多普勒显示治疗组患者经治疗后门静脉内径及脾静脉内径均明显下降(P<0.01),而门静脉血流速度较治疗前增加(P<0.05)o结论丹叶胶囊具有改善乙肝肝硬化患者血清肝纤维化指标和血流动力学的作用，对改善肝硬化进程有一定疗效。［关键词］乙型肝炎；肝硬化；丹叶胶囊［中图分类号］R575［文献标识码］A［文章编号］1674-4721(2013)07(a)-0095-03StudyonDanyecap
3、sulecombinedwithlamivudineandadefovirdipivoxilintreatmentofhepatitisBcirrhosisZHANGLaiZHANBo-linLIQunLiverDiseaseBranchofChineseTraditionalMedicalHospitalinShenzhenCityinGuangdongProvince,Shenzhen518033,China[Abstract]ObjectiveToobservethecurativeeffect
4、ofDanyecapsuleintreatmentofhepatitisBcirrhosis.Methods60casesofpatientswithhepatitisBcirrhosiswererandomlydividedintotwogroups,eachgroupwas30cases.Thepatientsincontrolgroupweregivenconventionalhepatoprotective+lamivudine+adefovirantiviraltherapy,thepati
5、entsintreatmentgroupwereaddedDanyecapsuleonthebasisofcontrolgroup,the1iverfunction(therecoveryrateofALT),HBV-DNAnegativeconversionrate,serumliverfibrosisindexes(IIA,LN,P-III~P,IV-C)andthechangeofliverhemodynamicsinthetwogroupsaftertreatmentwereobserved・
6、ResultsThetwogroupshadacertaineffect,buttheoveralleffectofthetreatmentgroupwassignificantlybetterthanthethatofcontrolgroup,thedifferencewasstatisticallysignificant(P<0.01)；thecontentsofserumliverfibrosismarkersIIA,LN,P-III-P,IV-Cintreatmentgroupafterthe
7、treatmentwassignificantlydecreased,andsignificantlybetterthanthatofcontrolgroup(卩<0.01)；atthesametime,colordopplershowedtheportalveindiameteranddiameterofsplenicveinofthepatientsintreatmentgroupwasdecreasedsignificantly(P<0.01),andtheflowvelocityofporta
8、iveinbloodwasincreasedthanbeforethetreatment(P<0.05)・ConclusionDanyecapsulecanimprovelivercirrhosisandhemodynamicsserumliverfibrosisindexesinpatientswithhepatitisB,andithasacertaineffectontheimprovementoflivercirrhosis.［Keywords］
