原发性高血压患者血清胱抑素C与心脏重构的关系-论文.pdf

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1、中华临床医师杂志r电子版)2013年12月第7卷第24期ChinJClinicians(ElectronicEdition)．December15．2013．V01．7．No．24·35·临床论著原发性高血压患者血清胱抑素C与心脏重构的关系黄茵黄涌泉薛金方陈晓波郭辉韩君勇林岫芳【摘要】目的研究原发性高血压(EH)患者血清胱抑素C(Cysc)与心脏重构的相关性。方法纳入收缩功能正常(LVEF>50％)的EH患者200例为试验组，纳入正常体检者50例为对照组，对上述对象进行血清CysC浓度检测并行超声心动图检查，测量左心房内径(LAD)、左心室舒张末期内径(LVDD)、室间隔厚

2、度(IVS)、左心室后壁厚度(LVPW)，并计算左心室重量指数(LVMI)；对照组上述指标正常，试验组根据血清CysC中位数浓度(1．05mg／L)分为CysC升高组(98例)及CysC正常组(102例)。结果试验组较对照组血清CysC浓度明显升高(P<0．05)。CysC升高组的LAD、LVDD、IVS、LVPw、LVMI较CysC正常组显著增高(P<0．05)。CysC含量与LAD、LVDD、IVS、LVPW、LVMI呈正相关关系(相关系数分别为0．422、O．381、0．367、0．256、0．350，P<0．05)，血清CysC浓度是心脏重构的显著影响因素。结论原发

3、性高血压患者血清CysC浓度与心脏重构相关，对高血压心脏重构的程度及预后判断有一定预测价值。【关键词】高血压；心室重构；超声心动描记术；胱抑素CStudyofthecorrelationbetweenthelevelofserumcystatinCandcardiacremodelinginpatientswithessentialhypertensionHUANGYin，HUANGYong-quan，XUEJin-fang,CHENXiao—bo,GUOHuLHANJun-yong,LIN)Ou-fang．DepartmentofCardiovascularMedicin

4、e,TheFifthA3~liatedHospitalofSun—YatSenUniversity,Zhuhai51900&ChinaCorrespondingauthor：LINXiu-fang,Email：linxiufang_126@126．com[Abstract]0bjeetiveTostudythecorrelationbetweenthelevelofsel'ulnCystatinCandcardiacremodelinginpatientswithessentialhypertension(EH)．MethodsTwohundredpatientsdiagn

5、osedasEH、thnormalheartfunctionand50normalcontrolswhohadmeasurementofCysCwereenrolledinthisstudy．Thenthegroupofpatientswithessentialhypertension，whoseLAD，LVDD，IVS，LVPWweremeasuredusingechocardiographyandLVM1wasevaluated，weredividedintotwogroupsbasedonthesenlrlCystatinClevel，ResultsTheSerumC

6、ysClevelinpatientswithhypertensionWashigherthanthatincontrolgroup(P<0．05)．WiththeincreaseofserumCysClevels，themesurementofLAD，LVDD，IVS，LVPWincreased．MultivariablestepwjseregressionanalysisshowedthatCysChadsignificantcorelation、vimLAD，LVDD，IVS，LVPW．WiththeincreaseofserunllevelsofCysC，thecar

7、diacremodelingwasmoreobvious．ConclusionTheserulTilevelofCysCwaspositivelyrelatedwithcadiacremodeling，theconcentrationofserumCysCmaybeapromisingpredictorofcardiacremodelingandprognosisinEH．[Keywords]Hypertension；Ventricularremodeling；Echocardiography；CystatinC高