依托泊苷联合洛铂或顺铂治疗广泛期小细胞肺癌的对照研究-论文.pdf

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1、第34卷第2期西安交通大学学报(医学版)Vo1．34No．22013年3月JournalofXi’anJiaotongUniversity(MedicalSciences)Mar．2O13依托泊苷联合洛铂或顺铂治疗广泛期小细胞肺癌的对照研究陈天君，高飞。，孙忠民，朱柏，THAKURAsmitanand，任徽，阳甜，陈明伟(西安交通大学医学院第一附属医院：1．呼吸内科；2．超声科，陕西西安710061)摘要：目的观察洛铂(1obaplatin，IBP)或顺铂(cisplatin，DDP)分别联合依托泊苷(etoposide，VP一16)治疗广泛期小细胞肺癌(smallcelllungcanc

2、er，SCLC)的近期疗效、不良反应和住院情况。方法46例广泛期SCIC分为DDP联合VP16的EP组23例，LBP联合VP一16的EL组23例。21d为1周期，连用2个周期评价近期疗效、毒性反应及住院情况。结果EL组和EP组比较，客观有效率、住院时间、白细胞下降率及血小板下降率，均无显著性差异。两组化疗后肺癌肿瘤标志物中神经元特异性烯醇化酶(NSE)均明显减低，但癌胚抗原(CEA)和细胞角蛋白19片段(cYFRA211)无明显减低，两组之间无显著性差异。EI组消化道反应率明显减低，但诊疗费用明显增加。结论EI和EP同样为广泛期SCLC安全有效的化疗方案，EI组消化道反应明显减少，但医疗费

3、用明显增加。关键词：依托泊苷；洛铂；顺铂；小细胞肺癌中图分类号：R734．2；R730．53文献标志码：A文章编号：16718259(2013)02—0198—04ComparativestudyoflobaplatinandcisplatincombinedwithetoposideforadvancedsmallcelllungcancerCHENTianjun，GaoFei，SUNZhong—min，ZHUBo，THAKURAsmitanand，RENHui，YANGTian，CHENMing—wei(1．RespiratoryDepartment；2．UltrasonicDepar

4、tment，theFirstAffiliatedHospital，MedicalSchoolofXi’anJiaotongUniversity，Xi’an710061，China)ABSTRACT：0bjectiveToobservetheshort—termtherapeuticeffect，adversereactionandhospitalizationconditionsoflobaplatinplusetoposide(EL)andcisplatinplusetoposide(EP)foradvancedsmallcelllungcancer(SCLC)．MethodsAtota

5、lof46patientswithadvancedSCLCwererandomizedintoELgroup(23patients)andEPgroup(23patients)．Thetwogroupsweretreatedfor21daysasonecyclefortwocycles．Theshort—termtherapeuticeffect，adversereactionandhospitalizationconditionsinthetwogroupswereevaluatedaftertwocycles．ResultsELgroupandEPgroupdidnotdiffersi

6、gnificantlyinobjectiveresponserate，hospitalstay，orrateofleukocyteandplateletdecrease．Inthetwogroups，NSEreducedsignificantlyafterchemotherapy，butCEAandCYFRA21-1didnot．Therewasnosignificantdifferencebetweenthetwogroups．InELgroup，theincidenceofgastrointestinalreactionreducedsignificantlywhereashospit

7、alizationcostincreasedsignificantly．ConclusionBothELandEPareasafeandeffectivechemotherapyforpatientswithadvancedSCLS．ComparedwithEPchemotherapy，ELchemotherapybringsasignificantdecreaseingastrointestinalreactionbu