妊娠期高血压疾病患者血清肌酐、尿素氮、尿酸联合检测的临床意义-论文.pdf

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1、生殖医学杂志2013年11月第22卷第11期．55．DOI：10．3969／j．issn．1004—3845．2013．11．009妊娠期高血压疾病患者血清肌酐、尿素氮、尿酸联合检测的临床意义周晓珍，娄甜平，周桂月(江苏省兴化市妇幼保健院，兴化225700)【摘要】目的探讨妊娠期高血压疾病患者血清肌酐(cr)、尿素氮(BuN)和尿酸(UA)联合检测的临床意义。方法选择2010年1月至2012年12月本院诊治的82例妊娠期高血压疾病患者作为观察组，其中妊娠期高血压34例(A组)，轻度子痫前期27例(B组)，重度子痫前期21例(C组)；选择同期正常妊娠孕晚期妇女作为对照组(55

2、例)。测定血清UA、Cr和BUN三项肾功能指标水平，并比较围产儿结局。结果妊娠期高血压疾病患者血UA水平明显高于正常对照组孕妇，且随着病情发展呈现明显上升趋势，与妊娠期高血压疾病的严重程度呈正相关性，并有统计学意义(P

3、lvalueofcombineddeterminationofserumcreatinine，ureanitrogenanduricacidinpatientswithgestationalhypertensionZH0UXiao—zhen，L0UTian—ping，ZHOUGui—YueDepartmentofGynecology&Obstetrics，XinghuaMaternalandChildHealthHospital，Jiangsuprovince，Xinghua225700[Abstract]objective：Tostudytheclinicalsignif

4、icanceofcombineddeterminationofserumcreatinine(Cr)，ureanitrogen(BUN)anduricacid(UA)inpatientswithgestationalhypertension．Methods：82patientswithgestationalhypertensionincluding34patientswithgestationalhypertension，27patientswithmildpreeclampsia，21patientswithseverepreeclampsiawereselectedin

5、ourhospitalfromJanuary2010tODecember2012astheobservationgroup．55patientswithnormallate—pregnantwereselectedasthecontrolgroup．TheserumlevelsofUA。CrandBUNweredetected．Theperinataloutcomeswererecorded．Results：Theserum1evelsofUAinthepatientswithgestationalhypertensionweresignificantlyhighertha

6、nthoseinthecontrolgroup，andincreasedwiththedevelopmentofdisease．Furthermore，theUAlevelswerepositivecorrelatedwiththeseverityofthegestationalhypertension(P~0．01)．HighserumlevelsofUAwereassociatedwithfetalgrowthrestriction，fetaldistressinuterus，neonatalasphyxiaandperinataldeath(P％0．05)．Concl

7、usions：SerumlevelsofUAcanreflecttheseverityofgestationalhypertensionandperinatalprognosis．IthasclinicalsignificanceinpredictingchangesofgestationalhypertensionandestimatingperinatalprognosisbymonitoringUAlevelsdynamically．【收稿日期】2013—05—07；【修回日期】2013—07—26【作者简介