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时间:2020-04-25
《喷他佐辛用于PPH超前镇痛的效果-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国肛肠病杂志2014年第34卷第8期15喷他佐辛用于PPH超前镇痛的效果汤国辉刘丽兵伍洲颂邓秋林南华大学附属南华医院肛肠外科(湖南衡阳421002)摘要为探讨喷他佐辛用于吻合器痔上黏膜环切术(PPH)超前镇痛的效果,将行PPH治疗的i00例混合痔患者随机分为治疗组和对照组,各5O例,两组患者均采用腰俞穴麻醉,治疗组术前10min予以喷他佐辛30rag肌肉注射,对照组术前10min予以生理盐水2ml肌肉注射,对比两组患者术中直肠牵拉反应情况、患者术后不同时点VAS评分及不良反应。结果显示,治疗组术中直肠牵拉反应情况明显优于对照组,P2、01;治疗组术后2h、4h、8hVAS评分均低于对照组,Pd0.05或Pd0.01;两组不良反应(如头晕、恶心、呕吐等)发生率比较差异无统计学意义,P>0.05。结果表明,喷他佐辛用于PPH超前镇痛,能安全有效地抑制术中直肠牵拉反应,术后镇痛效果确切、不良反应少,值得临床推广应用。关键词喷他佐辛;超前镇痛;吻合器痔上黏膜环切术;效果PreemptiveAnalgesiaEfficacyofPentazocineUsedbeforePPHTANGGuo—hui,L儿Li—bing,VUZhou—song,DENGQiu—linDept.of3、ColorectalSurgery,NanhuaHospitalAffiliatedtoNanhuaUniversity,Hengyang,Hunan421002AbstractThisstudywastoinvestigatethepreemptiveanalgesiaefficacyofPentazocineusedbeforePPH.The100caseswithmixedhemorrhoidstobesubjectedtoPPHwererandomlydividedintotreatmentgroupandcontrolone,54、0casesforeach;bothgroupswereallreceivedanesthesiaatYaoshupoint,10minbeforeoperationtreatmentgroupwasintramuscularlyinjectedwith30mgofPentazocine,whilecontrolgroupwithplacebo—normalsaline2ml;then,theintraoperativerectum—pulledresponse,thepostoperativeVASscoreandadversereac5、tionatdifferenttime—pointwerecomparedbetweenbothgroups.Asresults,therewasnostatisticaldifferencebetweenbothgroupSinadversereactions(e.g,dizziness,nausea,vomiting,etc)(P>0.05),butinintraoperativerectum—pulledresponsetreatmentgroupwassignificantlysuperiortocontrolgroup(Pd0.6、01),andinVASscorepostoperativeat2,4,8htreatmentgroupwasalllowerthancontrolgroup(Pd0.05,orP<0.01).ResultsshowthatPentazocineusedbeforePPHcaneffectivelyandsafelysuppressrectum—pulledreaction,hascertainanalgesiaefficacy,lessadversereaction,thusisworthytobepopularizedtousecli7、nically.KeyWordsPentazocine;Preemptiveanalgesia;PPH;Therapeuticeffect喷他佐辛(pentazocine,PTZ)是一种新的阿片用药。受体激动一拮抗药物,其可选择性地激动受体,具1资料与方法有良好的镇痛效应,且不良反应比吗啡少,已被广泛1.1临床资料选择2013年9月至2014年1月用于术后镇痛,但其在围手术期超前镇痛的应用鲜于我科行PPH治疗的i00例混合痔患者进行研究,见报道。吻合器痔上黏膜环切术(procedurefor患者均按照2006年中华医学会外科学分会结直肠p8、rolapseandhemorrhoids,PPH)是一种利用吻合器肛门外科学组等制定的《痔临床诊治指南》_1中相关环形切除直肠下段黏膜治疗Ⅲ、Ⅳ期内痔为主的标准确诊,手术麻醉方式均为腰俞穴麻
2、01;治疗组术后2h、4h、8hVAS评分均低于对照组,Pd0.05或Pd0.01;两组不良反应(如头晕、恶心、呕吐等)发生率比较差异无统计学意义,P>0.05。结果表明,喷他佐辛用于PPH超前镇痛,能安全有效地抑制术中直肠牵拉反应,术后镇痛效果确切、不良反应少,值得临床推广应用。关键词喷他佐辛;超前镇痛;吻合器痔上黏膜环切术;效果PreemptiveAnalgesiaEfficacyofPentazocineUsedbeforePPHTANGGuo—hui,L儿Li—bing,VUZhou—song,DENGQiu—linDept.of
3、ColorectalSurgery,NanhuaHospitalAffiliatedtoNanhuaUniversity,Hengyang,Hunan421002AbstractThisstudywastoinvestigatethepreemptiveanalgesiaefficacyofPentazocineusedbeforePPH.The100caseswithmixedhemorrhoidstobesubjectedtoPPHwererandomlydividedintotreatmentgroupandcontrolone,5
4、0casesforeach;bothgroupswereallreceivedanesthesiaatYaoshupoint,10minbeforeoperationtreatmentgroupwasintramuscularlyinjectedwith30mgofPentazocine,whilecontrolgroupwithplacebo—normalsaline2ml;then,theintraoperativerectum—pulledresponse,thepostoperativeVASscoreandadversereac
5、tionatdifferenttime—pointwerecomparedbetweenbothgroups.Asresults,therewasnostatisticaldifferencebetweenbothgroupSinadversereactions(e.g,dizziness,nausea,vomiting,etc)(P>0.05),butinintraoperativerectum—pulledresponsetreatmentgroupwassignificantlysuperiortocontrolgroup(Pd0.
6、01),andinVASscorepostoperativeat2,4,8htreatmentgroupwasalllowerthancontrolgroup(Pd0.05,orP<0.01).ResultsshowthatPentazocineusedbeforePPHcaneffectivelyandsafelysuppressrectum—pulledreaction,hascertainanalgesiaefficacy,lessadversereaction,thusisworthytobepopularizedtousecli
7、nically.KeyWordsPentazocine;Preemptiveanalgesia;PPH;Therapeuticeffect喷他佐辛(pentazocine,PTZ)是一种新的阿片用药。受体激动一拮抗药物,其可选择性地激动受体,具1资料与方法有良好的镇痛效应,且不良反应比吗啡少,已被广泛1.1临床资料选择2013年9月至2014年1月用于术后镇痛,但其在围手术期超前镇痛的应用鲜于我科行PPH治疗的i00例混合痔患者进行研究,见报道。吻合器痔上黏膜环切术(procedurefor患者均按照2006年中华医学会外科学分会结直肠p
8、rolapseandhemorrhoids,PPH)是一种利用吻合器肛门外科学组等制定的《痔临床诊治指南》_1中相关环形切除直肠下段黏膜治疗Ⅲ、Ⅳ期内痔为主的标准确诊,手术麻醉方式均为腰俞穴麻
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