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时间:2020-04-25
《亮菌防治顺铂化疗诱发胃肠道反应的胃肌电研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华肿瘤防治杂志2012年8月第19卷第1塑垒垦垦垦垦!垦垒!!垒!!!!::《实验研究/论著l亮菌防治顺铂化疗诱发胃肠道反应的胃肌电研究杜静李平张梅汪克明蔡荣林孙鑫1.安徽医科大学附属省立医院中医肿瘤科,安徽合肥2300012.安徽中医学院经脉脏腑相关研究中心,安徽合肥230038【摘要】目的:探讨外源性亮菌抗顺铂(DDP)化疗过程中并发胃肠道反应的胃平滑肌电活动机制。方法:90只雄性SD大鼠随机分为空白对照组、模型组、亮茵低、中、高剂量组及昂丹司琼组6组,参照DeJonghe法以6mg/kg体质量腹腔注射DDP制造化疗性大鼠异食癖恶心呕吐模型,采用Biopac专用胃肠电记录分析系
2、统检测胃窦部平滑肌电活动,观察亮茵对DDP复制模型后不同时间段的胃电活动的影响。结果:造模后24~72h,亮菌高、中剂量组大鼠高岭土摄入量均显著低于模型组(P3、:4.13±1.14,AV:163.46±26.14)的差异最明显。结论:亮茵可有效抑制DDP化疗所诱发的胃节律性运动紊乱,尤以造模后24h亮菌高剂量组最为明显,亮菌对大鼠DDP化疗过程中诱发的胃肠道反应的抑制作用机制可能与胃节律性运动有关。【关键词】真菌;胃电图描记;药物疗法;呕吐中华肿瘤防治杂志,2012,l9(15):1131一ll34ExperimentalstudyoftheelectrogastrogramofArm~liar~ellatabescensfortheprevention0fcispIatin—inducedgastrOintestinaltractreac4、tionintheratDUJing,LIPing,ZHANGMei,WANGKe—ming,CAIRong—lin,SUNXin1.Depa~mentofChineseMedicine,ProvincialHospitalAfflicatedtoAnhuiMedicalUniversity,Hefei230001,P.R.China2.ResearchCentreontheCorrelationbetweenChannelsandViscera,AnhuiCollegeofTraditionalChineseMedicine,Hefei230038,P,R.China[ABSTRA5、CT]OBJECTIVE:TostudyofthegastricelectricalactivityofArmillariellatabescensforthepreventionofchemotherapy-inducedgastrointestinaltractreactionbycisplatin.METHODS:NinetymaleSprague-Dawleyratswereran—domizedintocontrolgroup,modelgroup,low,middleandhighdoseofArm~liar~ellatabescensgroups,ondansetron6、group.Ratswereinjectedintraperitoneallywithcisplatin6mg/kgtoinducepicaaccordingtomethodofDeJonghe,byusingbio—logicalfunctionofexperimentalsystemtorecordandanalyzeelectricalactivityinsmoothmuscleofgastricantruminrat,toobservetheeffectivenessofArm~liar~ellatabescenstogastricelectricalactivityindi7、fferenttimeafterreplicationpicamodelbyDDP.RESULTS:24—72haftercisplatinadministration,inthemiddleandhighdoseofArm~liar~ellatabescensgroups,kaolinintakewaslowersignificantlycomparedtointakeinthemodelgroup,respectively(P
3、:4.13±1.14,AV:163.46±26.14)的差异最明显。结论:亮茵可有效抑制DDP化疗所诱发的胃节律性运动紊乱,尤以造模后24h亮菌高剂量组最为明显,亮菌对大鼠DDP化疗过程中诱发的胃肠道反应的抑制作用机制可能与胃节律性运动有关。【关键词】真菌;胃电图描记;药物疗法;呕吐中华肿瘤防治杂志,2012,l9(15):1131一ll34ExperimentalstudyoftheelectrogastrogramofArm~liar~ellatabescensfortheprevention0fcispIatin—inducedgastrOintestinaltractreac
4、tionintheratDUJing,LIPing,ZHANGMei,WANGKe—ming,CAIRong—lin,SUNXin1.Depa~mentofChineseMedicine,ProvincialHospitalAfflicatedtoAnhuiMedicalUniversity,Hefei230001,P.R.China2.ResearchCentreontheCorrelationbetweenChannelsandViscera,AnhuiCollegeofTraditionalChineseMedicine,Hefei230038,P,R.China[ABSTRA
5、CT]OBJECTIVE:TostudyofthegastricelectricalactivityofArmillariellatabescensforthepreventionofchemotherapy-inducedgastrointestinaltractreactionbycisplatin.METHODS:NinetymaleSprague-Dawleyratswereran—domizedintocontrolgroup,modelgroup,low,middleandhighdoseofArm~liar~ellatabescensgroups,ondansetron
6、group.Ratswereinjectedintraperitoneallywithcisplatin6mg/kgtoinducepicaaccordingtomethodofDeJonghe,byusingbio—logicalfunctionofexperimentalsystemtorecordandanalyzeelectricalactivityinsmoothmuscleofgastricantruminrat,toobservetheeffectivenessofArm~liar~ellatabescenstogastricelectricalactivityindi
7、fferenttimeafterreplicationpicamodelbyDDP.RESULTS:24—72haftercisplatinadministration,inthemiddleandhighdoseofArm~liar~ellatabescensgroups,kaolinintakewaslowersignificantlycomparedtointakeinthemodelgroup,respectively(P
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