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时间:2020-04-24
《组织弥散定量分析运用于肝纤维化程度判定的研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、医学影像学杂志2014年第24卷第6期JMedImagingVo1.24No.62014组织弥散定量分析运用于肝纤维化程度判定的研究靳元(黑龙江省大庆龙南医院物理诊断科(齐齐哈尔医学院第五附属医院)黑龙江大庆163453)【摘要】目的探讨超声弹性成像组织弥散定量分析对肝纤维化程度判定的应用价值,以期为肝病患者的病情评估及早期预防提供方法。方法选取2011年1月~2013年7月消化内科15O例慢性乙肝患者为试验组研究对象,行肝脏穿刺术,根据肝纤维化病理分期标准分为5期(sO~S4)。另选取健康志愿者4O例为对照组。所有研究对象均行超声成像检查
2、组织弥散定量分析。比较试验组与对照组研究对象中11项组织弥散特征量之间的差异性,并根据统计学结果,将有统计学意义的指标进行试验组不同病理分期患者组内比较,并分析其与肝纤维化病理分期的相关性。结果在11个弹性特征量中,试验组应变均值较对照组明显降低,蓝色领域百分比较对照组明显增高,差异有统计学意义(P均<0.05)。在试验组患者中,随着肝纤维化病理分期的增高,应变均值逐渐降低,而蓝色领域百分比逐渐增高,结果具有统计学意义(P均3、0.ooo),与蓝色区域所占百分比存在显著正相关关系(r:o.913,P:0.000)。结论超声弹性成像组织弥散定量作为一种无创监测技术能够间接判断肝纤维化病理分期的程度,值得在临床上广泛应用,对肝病患者疾病的评估及早期预防性治疗,具有重要意义。【关键词】肝纤维化;超声弹性成像;组织弥散定量分析中图分类号:R575:R445.1文献标识码:A文章编号:1006—9011(2014)06—0970—04Theapplicationofquantitativeanalysisoftissuediffusioninthedegreeofliver4、fibrosisjINYuanDepartmentofPhysicalDiagnosis,HeilongJiangDaqingLongnanHospital(QiqiharMedicalCollegeAffiliatedHos—pital5),Daqing163453,P.R.China[Abstract]ObjectiveToinvestigatetheapplicationofquantitativeanalysisoftissuediffusioninthedegreeofliverfibro—sissoastoprovidemeth5、odsforliverconditionofthepatientassessmentandearlyprevention.Methods150casesofchro—nichepatitisBwereselectedinourhospitalbetweenJanuary,2011toJuly。2013.Fiveperiods(SO~S4)weredividedaccordingtoliverfibrosisstagingstandardsafterliverpuncture.Another40healthyvolunteersweresel6、ectedasthecontrolgroup.Allsubjectswereanalyzedbyultrasoundimagingwithtissuediffusionquantitativetechnology.11tissuedispersioncharacteristicquantitiesbetweenexperimentalgroupandthecontrolgroupofsubjectswerecompared.Andthestatisticallysignificantindicatorswerecomparedinthepa7、tientswithdifferentpathologicalstaging.Correlationwasanalyzedbetweenthemandthepathologicalstaging.ResultsAmongthe11elasticcharacteristicquantities,theaveragerelativestrainvalueintheexperimentalgroupwassignificantlylowerthanthatinthecontrolgroup(P8、reaintheexperimentalgroupwassignificantlyhigherthanthatinthecontrolgroup(P
3、0.ooo),与蓝色区域所占百分比存在显著正相关关系(r:o.913,P:0.000)。结论超声弹性成像组织弥散定量作为一种无创监测技术能够间接判断肝纤维化病理分期的程度,值得在临床上广泛应用,对肝病患者疾病的评估及早期预防性治疗,具有重要意义。【关键词】肝纤维化;超声弹性成像;组织弥散定量分析中图分类号:R575:R445.1文献标识码:A文章编号:1006—9011(2014)06—0970—04Theapplicationofquantitativeanalysisoftissuediffusioninthedegreeofliver
4、fibrosisjINYuanDepartmentofPhysicalDiagnosis,HeilongJiangDaqingLongnanHospital(QiqiharMedicalCollegeAffiliatedHos—pital5),Daqing163453,P.R.China[Abstract]ObjectiveToinvestigatetheapplicationofquantitativeanalysisoftissuediffusioninthedegreeofliverfibro—sissoastoprovidemeth
5、odsforliverconditionofthepatientassessmentandearlyprevention.Methods150casesofchro—nichepatitisBwereselectedinourhospitalbetweenJanuary,2011toJuly。2013.Fiveperiods(SO~S4)weredividedaccordingtoliverfibrosisstagingstandardsafterliverpuncture.Another40healthyvolunteersweresel
6、ectedasthecontrolgroup.Allsubjectswereanalyzedbyultrasoundimagingwithtissuediffusionquantitativetechnology.11tissuedispersioncharacteristicquantitiesbetweenexperimentalgroupandthecontrolgroupofsubjectswerecompared.Andthestatisticallysignificantindicatorswerecomparedinthepa
7、tientswithdifferentpathologicalstaging.Correlationwasanalyzedbetweenthemandthepathologicalstaging.ResultsAmongthe11elasticcharacteristicquantities,theaveragerelativestrainvalueintheexperimentalgroupwassignificantlylowerthanthatinthecontrolgroup(P8、reaintheexperimentalgroupwassignificantlyhigherthanthatinthecontrolgroup(P
8、reaintheexperimentalgroupwassignificantlyhigherthanthatinthecontrolgroup(P
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