前列地尔治疗不稳定型心绞痛临床疗效及对相关细胞因子水平的影响-论文.pdf

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1、浙江中西医结合杂志2014年第24卷第7期ZhejiangJITCWM(Vo1．24No．72014)583前列地尔治疗不稳定型心绞痛临床疗效及对相关细胞因子水平的影响王建军-李开军：1浙江省青田县人民医院心内科青田3230002浙江省丽水市中心医院心内科摘要目的观察前列地尔治疗不稳定性心绞痛临床疗效及对血白细胞素6、10(IL一6、IL一10)、肿瘤坏死因子ot(TNF一0【)水平的影响。方法不稳定心绞痛患者80例，随机分为对照组(40例)和治疗组(40例)。对照组患者给予常规对症支持治疗，观察组患者在对照组基础上加用前列地尔治疗，

2、比较两组临床效果、心电图改善情况、血IL一6、TNF—、IL一10水平。结果治疗后，治疗组心绞痛、心电图显效率(42．5％、47．5％)均明显高于对照组(20．O％、25．O％)，差异有统计学意义=5．431，6．243，P<0．05)；两组治疗后血IL一6、TNF一仅水平较治疗前明显降低、IL一10水平明显升高(P

3、cyofAlprostadilTreatmentforUnstableAnginaandItsEfectonIL-6，TNF-a,IL-10WANGJianjun‘，LIKaijun．JDepartmentofCardiovascularDiseases，PeopleHospitalofQingtian，Qingtian(323000)，Chi—na；2DepartmentofCardiovascularDiseases，CentralHaspitalofLishuiABSTRACT0bjectiveToinvestigatethec

4、linicaleficacyofalprostadilinthetreatmentofunstableanginaanditseffectonlevelsofinterleukin—IO(IL一10)，interleukin一6(IL一6)andtumornecrosisfactor～o【(TNF—Ot)．MethodsEightypatientswithunstableanginaadmittedinCardiovascularDepartmentofPeopleSHospitalofQingtianandCentralHospit

5、alofLishuifromJanuary，2012toJanuary，2013wereenrolledinthisstudy．Thepatientsweredividedintotwogroups：controlgroup(n=40)andtreatmentgroup(n=40)．Thepatientincontrolgroupwasgivengeneralsymptomaticandsuppo~ivetreatmentandthepatientintreatmentgroupwasgivenalprostadilplusgener

6、alsymp-tomatictreatment．Clinicaleffects，ECGimprovement，andthelevelofIL一6，TNF—Q，IL一10werecomparedbetweentwogroups．ResultsTheclinicaleficacyintreatmentgroupwashigherthanthatincontrolgroup(42．5％VS20％)，withastatisticaldiference(=5．431，P

7、wasseenintreatmentgroup(47．5％VS25％=5．431，P<0．05)．Aftertreatment，thelevelofIL-6andTNF-ainbothgroupsweresignifi-cantlylowerandthelevelofIL一10washigherthanthosebeforetreatment(P<0．05)：thelevelofIL一6andTNF—QintreatmentgrouphadmoredecreaseandthelevelofIL-IOhadmoreincreasetha

8、nthoseincontrolgroupaftertreatment(P<0．05)．ConclusionAlprostadilcaneffectivelysuppressinflammationandimprovecl