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《阿立哌唑对利培酮所致催乳素升高的作用研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、实用药物与临床2014年第l7卷第7期PracticalPharmacyAndClinicalRemedies,2014,Vo1.17.No.7·871·阿立哌唑对利培酮所致催乳素升高的作用研究沈子童[摘要]目的探讨阿立哌唑对男性抗精神病药所致的高催乳素(PRL)副作用的治疗作用。方法对74例利培酮治疗的男性精神分裂症患者随机分组,均采用利培酮治疗,起始1mg/d,并根据精神症状调整药量至治疗量4~6mg/d。研究组于第3周开始加用阿立哌唑5mg/晚,直至研究结束不再增加阿立哌唑剂量,分别于0、2、4、8、12周末进行催乳素检测,对治疗中
2、出现的其他不良反应进行TESS评定。结果加用阿立哌唑后,研究组PRL在l2周末时(164.54±69.26)ixlU/mL与基线期(151.97±64.66)pAU/mL比较差异无统计学意义(P=0.435,t=0.785),而对照组第2周后PRL持续增高(177.28±45.18)IMU/mL,第4周末时明显异常(351.41±61.56)ixlU/mL。但第8周(379.59±73.62)bdU/mL和12周(382.50±76.89)pJU/mL相比较变化不大两组不良反应发生率差异无统计学意义(=3.12,P=0.077)。但不良反
3、应的构成存在一定差异,研究组静坐不能7例(20%),震颤6例(17.14%),头痛11例(31.43%),肌强直3例(8.57%),对照组静坐不能10例(31.25%),震颤9例(28.12%),肝功能异常3例(9.38%),肌强直9例(28.13%),便秘6例(18.75%),体重增加11例(34.38%)。结论阿立哌唑对于利培酮导致的男性催乳素升高有一定的控制及治疗作用。且两药联用并未增加副N-应的风险。[关键词]催乳素;分裂症;阿立哌唑;利培酮Effectofaripiprazolonincreasedprolactincaused
4、byrisperidoneSHENZi—tong(SuzhouSecondPeoplesHospital,Anhui234000,China)[Abstract]ObjectiveTodiscussthetreatingrolesofaripiprazoleforthehighprolactionlevelcausedbymaleantipsychoticdrugs.Methods74maleschizophrenicstreatedbyrisperidonewererandomlygrouped.Foreveryschizo—phren
5、ic,risperidonewasusedbeginningwith1mg/d,anddoseswereadjustedto4~6mg/daccordingtothementalsymptoms.Atthethirdweek,theresearchgroupwasaddedby5mgeverynightofaripiprazoleandthedosewasnotincreaseduntiltheresearchwasover.Prolactintestsweremadeattheendofweek0,week2,week4,week8,a
6、ndweek12,andTESSassessmentsforotheradversereactionsduringthetreatment.ResultsFortheresearchgroup,therewasnosignificantdifference(P=0.435,t=0.785)forthePRLlevelbetweenattheendofweek12(164.54±69.26)andatthebaselineperiod(151.97±64.66),meanwhileforthecontrolgroup,PRLlevelcon
7、tinuedtoincreaseafterweek2(177.28±45.18),withobviousdifferenceattheendofweek4(351.41±61.56).However,forweek8(379.59±73.62)andweek12(382.50±76.89),therewasnosignificantdifferenceforthetwogroups.Theoccurrencerateofadversereactionsofthetwogroupswasbasicallyequal(=3.12,P=0.07
8、7),withnostatisticalsignificance.Intheresearchgroup,therewere7casesofakathisia(20%),6casesoftrem
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