鸦胆子油乳联合调强放疗及腔内后装治疗宫颈癌的临床观察.pdf

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1、·1928·邓守恒．等鸦胆子油乳联合调强放疗及腔内后装治疗宫颈癌的临床观察鸦胆子油乳联合调强放疗及腔内后装治疗宫颈癌的临床观察邓守恒，陈萍ClinicalobservationofbruceaeoilemulsioncombinedwithradiotherapyandafterloadingintracavitarybrachytherapyinpatientswithcervicalcancerDengShouheng，ChenPingCenterofOncology，PeopleHospital，HubeiUniversityofMedicine，HubeiS

2、hiyan4420o0，China．【Abstract】Objective：Toinvestigatetheefect，localcontrolrate，lifequalityandcomplicationsofbruceaeoile—mulsioncombinedwithintensitymodulatedradiationtherapy(IMRT)andIrafterloadingintracavitarybrachthera—pyinpatientswithcervicalcancer．Methods：Sixty—eightcervicalcancerpati

3、entsweredividedrandomlyintotwogroups，thecontrolgroup(34cases)andtheobservationgroup(34cases)．BothgroupsreceivedIMRTplusintracav‘itarybrachytherapy(1．8—2．2Gyperfraction，5fractionsperweek，withanaveragedoseof54．5Gy)．Intracavitarybrachtherapywastoatotaldoseof24—30Gyat6Gyperfractiononceawee

4、kafterthedoseofIMRTreached30Gy．Theobservationgroupreceived30mlofbruceaeoilemulsiononceadayfor21days．Results：Theeffectiveratesoftwogroupswere85．29％and88．24％andtherewasnodifferenceinthetwogroups(P>0．05)．Aftertreatment，thelevelofCD3，CD4wasobviouslyincreasedintheobservationgroup(P<0．05)，wh

5、ileinthecontrolgroup，thelev—elofCD3，CD8wasobviouslydecreasedaftertreatment(P<0．05)．ThelevelofCD3，CIM，CD8andCD56beforetreatmentintwogroupswerenotsignificantlydifferent(尸>0．05)，aftertreatment，thelevelofCD3，CIM，CD8andCD56intheobservationgroupwerehigherthanthoseinthecontrolgroup(P<0．05)．Th

6、etoxiceffectswerecomparedintwogroups，theacuteradiationenteritisandhematologytoxicintheobservationgroupwereobviouslylowerthanthoseinthecontrolgroup(P<0．05)．Conclusion：Bmceaeoilemulsioncouldenhancethesen—sitivityofcervicalcancercellstoIMRTandintracavitarybrachytherapythroughimprovingthec

7、ellimmunologicrune—tionandavoidingordecreasingsideeffect，improvethetimeandquality．【Keywords】eervialcancer；brueeaeoilemulsion；IMRT；intraeavitarybrachytherapyModemOneology2014，22(08)：1928—1930【摘要】目的：观察中药鸦胆子油乳配合调强放疗(IMRT)及。Ir腔内后装治疗宫颈癌的近期有效率及毒副反应。方法：68例宫颈癌患者随机分为2组，对照组34例，全程IMRT配合腔内后装治疗。研