欢迎来到天天文库
浏览记录
ID:53731767
大小:318.94 KB
页数:4页
时间:2020-04-20
《西妥昔单抗联合放化疗治疗局部晚期鼻咽癌的临床疗效观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、肿瘤药学2013年4月第3卷第2期Anti—tumorPharmacy,April2013,Vo1.3,No.2—119蜥西妥昔单抗联合放化疗治疗局部晚期鼻咽癌的临床疗效观察唐冬寒,张钰霞,蔡静(毕节市人民医院,贵州毕节,551700)摘要:目的探讨西妥昔单抗联合同期顺铂化疗加调强放疗治疗局部晚期鼻咽癌的临床疗效及安全性。方法选择2009年1月至2(J12年1月我院收治的晚期鼻咽癌患者11()例为研究对象,随机分为对照组和观察组,每组55例,对照组患者给予单纯调强适形放射治疗,而观察组患者给予西妥昔单抗联合同期顺铂化疗加调强放疗.治
2、疗4个周期后比较两组患者的}临床疗效及其不良反应的发生情况..结果对照组和观察组的治疗总有效率分别为74.5%和92.7%,观察组明显高于对照组(P<().05)。两组患音治疗过程中均出现不同程度的恶心、呕吐等消化道反应及骨髓抑制,经对症处理后,明显好转;观察组患者皮肤痤疮样皮疹及口腔黏膜炎的发生率明显高于对照组(P<{).05)。结论西妥昔单抗联合同期顺铂化疗加调强放疗治疗局部晚期鼻咽癌的近期疗效好,但不良反应多,临床需综合考虑后推广应用。。关键词:西妥昔单抗;顺铂;调强放疗;鼻咽癌;临床疗效中图分类号:R73963文献标识码:A
3、文章编号:2()95—1264(2013)02—0119一(14doi:10.396%j.issn.2(}95-12642013.028TheClinicalEficacyofCetuximabCombinedwithRadiotherapyandChemotherapyintheTreatmentofLocallyAdvancedNasOpharyngealCarcinomaDonghan,ZhangYuxiaCaiJingfThePeoplesHospital0』B记City,B,Gu~hou,551700,China)Abst
4、ract:ObjectiveToinvestigatetheeficacyandsafetyofcetuximabcombinedwithcisplatinchemotherapyandintensity—modulatedradiotherapyinthetreatmentoflocallyadvancednasopharyngealcarcinoma.Methods11()casesoflo-callyadvancednasopharyngealcarcinomahospitalizedfromJanuary2()09toJan
5、uary2012wereselectedandrandomlydividedintothecontrolgroupandobservationgroup(55casesineachgroup).Thecontrolgroupwastreatedbyintensity—modulatedradiotherapy,whiletheobservationgroupwastreatedbycetuximabcombinedwithcisplatinchemotherapyandintensity——modulatedradiotherapy
6、.Theclinicaleficacyandincidencerateswerecomparedbetweentwogroupsafter4treatmentcy——clesResultsThetotalefectiveratesofcontrolgroupandobservationgroupwererespectively74.5%and927%.whichwassignificantlyhigherintheobservationgroup<().o5)Gastrointestinalreactionssuchasnausea
7、andvonfittingaswellasmyelosuppressjonwereobservedintwogroups,butwereobviouslyimprovedaftersymptomatictreatment.Theincidenceratesofacne—likerashandora1nmcositisweresignificantlyhigherintheobservationgroupthanthoseofthecontrolgroup<0.()5)ConclusionCetuximabpluscisplatinc
8、hemotherapyandintensity—modulatedradiotherapvhadbetterclinicalef-ficacybutnloreadversereactionsinthetreatmentoflocall
此文档下载收益归作者所有