全身化疗联合顺铂胸腔灌注治疗非小细胞肺癌恶性胸腔积液的临床观察.pdf

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1、·1O12·西部医学2013年7月第25卷第7期MedJWestChina，July2013，Vo1．25，No．7全身化疗联合顺铂胸腔灌注治疗非小细胞肺癌恶性胸腔积液的临床观察朱江红，高云，杨胜利，苏敏，庞洁，何兴平，代军(攀枝花市中心医院肿瘤血液科，四川攀枝花617000)【摘要】目的观察全身化疗联合顺铂胸腔灌注治疗肺癌恶性胸腔积液的近期疗效及毒副反应。方法回顾性分析收治的42例经临床病理确诊的非小细胞肺癌伴恶性胸腔积液患者临床资料。其中联合组22例：采用胸腔置入中心静脉导管排尽胸水后给予顺铂60mg第1、8天灌注，同时静脉输注化疗药物吉西他滨1000mg／m2第1

2、、8／21天(GP方案)或紫杉醇6O一90mg／m。第1、8／21天(TP方案)；单药组20例：顺铂60mg第1、8天灌注，21天重复，共治疗3个周期，评价近期疗效、观察毒副反应。结果42例患者均完成3个周期的治疗，可评价疗效，联合组总有效率为81．8，单药组为6O．O。结论联合用药方案治疗非小细胞肺癌伴恶性胸腔积液疗效明显优于单药治疗(P<0．05)，且较安全，值得临床推广应用。【关键词】非小细胞肺癌；全身化疗；顺铂；胸腔灌注；胸腔积液【中图分类号】R734．2【文献标识码】Adoi：10．3969／j．issn．1672—3511．2013．07．020Effect

3、ofSystemicChemotherapyCombinedwithInfusionofCisplatinintoThoracicCavityintheTreatmentofMalignantPleuralEffusionofNon。smallCellLungCancerZHUJian~hong，GAOYun，YANGSheng-li，etal(DepartmentofHematologyOncology，TheCentralHospitalofpanzhihua．panzhihua617067．Sichuan，China)[Abstract]ObjectiveToev

4、aluatetheclinicalefficacy，adverseeffectsofsystemicchemotherapycombinedwithin—fusionofcisplatinintothoraciccavityinthetreatmentofmalignantpleuraleffusionofnon—smal1celllungcancer．MethodsClinica1dataof42patientswithmalignantpleuraleffusionduetonon-smallcelllungcancer．whichwereprovedbypa·th

5、ology，wereanalizedretrospectively．22patientsreceivedcombinedtherapy：infusionofeisplatinintothoraeiecavityatadoseof60mgOnday1andday8，alongwithintravenousperfusionofgemcitabineatadoseof1000mg／m2onday1andday8orpaclitaxelof60—90rag／m2onday1andday8．2Opatientsreceivedsingletherapy：infusionofci

6、splatinintotho-raciccavityatadoseof60mgonday1andday8．Therapywasrepeatedevery21daysforonecycle．Theclinicaleffica—cy，adverseeffectswereevaluatedafter3cycles．ResultsAll42patientscompletedthe3cyclesoftreatment．Incom—binedgroup，thetotaleffectiverateoftreatmentwas81．8％．Insinglegroup，theeffecti

7、verateoftreatmentwas60．ConclusionThecombinedtherapyformalignantpleura1effusionofnon-smal1celllungcanceriseffectiveandsafe，whichisvaluableinclinicalapplication．[Keywords]Non—smallcelllungcancer；Systemicchemotherapy；Cisplatin；Thoracicperfusion；Malignantpleuraleffusion肺癌是常见的