帕金森病患者血浆同型半胱氨酸水平与认知功能障碍相关性研究.pdf

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1、JournalofChinaPrescriptionDrugVo1．12No．8·论著·3帕金森病患者血浆同型半胱氨酸水平与认知功能障碍相关性研究蔡江萍，李国前，洪全龙，魏晓兰，黄丹霞(福建医科大学附属泉州I第一医院神经内科，泉州362000)【摘要】目的探讨帕金森病(Parkinson’sdisease，PD)患者血浆同型半胱氨酸(Homocysteine，Hcy)水平与认知功能障碍的相关性。方法选取106例PD患者(包含认知障碍者55例，认知正常者51例)及50例健康对照者，收集临床资料、认知功能评估，应用高效液相色谱法测定血浆Hcy浓度，放射免疫法测定血

2、浆叶酸、维生素B，浓度，分析血浆Hey含量与认知功能的相关性。结果认知障碍组血浆Hcy值显著高于认知正常组，差异具有统计学意义(P

3、withParkinson’sdiseaseCAIJiang-ping，LIGuo—qian，HONGQan—long，eta1．DepartmentofNeurology，FirstAfiliatedHospitalofQuanzhou，FujianMedicalUniversity，Quanzhou362000，China．【Abstract】0bjectiveTostudytheassociationbetweenthelevelofplasmahomocysteine(Hcy)andthecognitivedysfunctioninpatientswi

4、thParkinson’sdisease(PD)．MethodsTotal156subjectswereenrolled，including50unrelatedhealthycontrolsand106patientswithPD．Thebasicinformation，diseasesituationandcognitivefunctionofpatientswithPDwereinvestigatedandtheplasmaconcentrationsofHey，folieacidandvitaminBl2weredetectedineachsubjec

5、t．TherelationshipbetweenplasmaHeylevelsandthecognitivefunctionwasassessed．ResultsTheplasmaHeyconcentrationsofcognitivedysfunctiongroupwerehigherthanthoseofnormalcognitivegroup[(21．5±5．1)gmmol／Lvs(14．7±4．7)p,mmol／L，P<0．05]andtherewerenodifferencesinplasmaconcentrationsoffolicacidandv

6、itaminB12amongthegroups．ThescoresoftheMini—mentalstateexamination(MMSE)andMontrealcognitiveassessment(MoCA)allshowedsignificantcorrelationswithplasmaHcyinpatientswithPD．ConclusionTheelevatedplasmaHcylevelissignificantlyassociatedwiththecognitivedysfunction．TheincreaseofplasmaHcymayb

7、eoneofthemainimportantriskfactorsofcognitivedysfunctioninPDpatients．【Keywords】Parkinson’sdisease；Cognitivedysfuetion：Plasma；Homocysteine帕金森病(Parkinson’sdisease，PD)是常见的神经系统变营养不良、吸烟、酗酒及长期摄人咖啡等。⑦本研究前6个月内性病，主要的临床表现是运动迟缓、肌僵硬、静止性震颤和姿势服用过叶酸、B族维生素、抗癫痫药物、避孕药等可能影响血浆不稳，其非运动症状，如认知障碍、情绪障碍也引起广泛的重

8、视。Hcy水平的药物。PD患者中发生认