两种 HAART 方案对 HIV／AIDS患者血脂的影响.pdf

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1、2574重庆医学2014年7月第43卷第2O期论著·临床研究doi：10．3969／i．issn．16718348．2014．20．011两种HAART方案对HIV／AIDS患者血脂的影响李虹，陈媛媛，何云，李超锋，刘春礼，孙燕，赵清霞A(河南省郑州市第六人民医院感染科450015)摘要：目的观察两种高效抗逆转录病毒治疗(HAART)方案应用48周对HIV／AIDS患者血脂的影响。方法将102例HIV／AIDS患者根据不同的HAART方案分为司他夫定(D4T)组[D4T联合拉米夫定(3TC)及奈韦拉平(NVP)治疗]

2、和齐多夫定(AZT)组(AZT联合3TC及NVP治疗)。检测基线及HAART后24、48周时的三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL—C)水平。结果配对t检验分析，D4T组患者24周TG、TC和LDL-C均显著升高(P0．05)。结论包含D4T和AZT的HAART方案均可导致HIV／AID

3、s患者血脂异常，主要是TG和TC升高，均以边缘升高为主。应用包含D4T的方案的HIV／AIDs患者TG和TC升高较早，并且TC升高后持续保持在较高的水平。关键词：抗逆转录病毒治疗，高效；获得性免疫缺陷综合征；HIV；血脂中图分类号：R512．91文献标识码：A文章编号：167卜8348(2014)20—2574—03TheimpacttobloodlipidinpatientswithHIV／AIDSusingtwodifferentHAARTregimensLiHong，ChenYuanyuan，HeYun，LiC

4、haofeng，LiuChunli，SunYah，ZhaoQingxia(InfectiousDiseases，theSixthPeopleHospitalofZhengzhouCity，Zhengzhou，Hennan450015，China)Abstract：0bjectiveTounderstandtheimpacttobloodlipidinpatientswithHIV／AIDSusingdifferentHAARTregimens．MethodsAccordingtoHAARTregimens，102HI

5、V／AIDSpatientsweredividedintotwogroups：D4Tgroup(D4T+3TC+NVP)andAZTgroup(AZT+3TC+NVP)．Bloodlipids(TG，TC，I．DI．-CandHDL-C)atbaseline，24weeksand48weeksafterHAARTweredetected．ResultsComparedwithpairedttest，TG，TCandLDL-Cat24weeksfollow-upofthepatientsinD4Tgroupweresi

6、gnificantlyhigherthanatbaseline(P~0．05)，andTCat48weeksfollowupwerestillhigherthanatbaseline(P<0．05)．TGandTCat24weeksfollow—upofpatientsinAZTgroupweresignificantlyhigherthanatbaseline(P~0．05)．Therewerenosignificantdifferenceatbloodlipidbetweenthetwogroups(P>0．05

7、)．ConclusionTherearedyslipidemiaofthepatientswithHIV／AIDSu—singD4T—basedandAZT-basedregimens．andthedyslipidemiaareincreaseofTCandTG，theseincreaseisborderhigher．TGandTCat24weeksfollow-upoftheHIV／AIDSpatientsusingD4T—basedregimenareincreasedearly，andTCarestillath

8、igherleve1．Keywords：antiretroviraltherapy，highlyactive；acquiredimmunodefieiencysyndrome；HIV；lipids高效抗逆转录病毒治疗(highlyactiveantiretroviralthera—经疾病者；依从性差，无法保证随访者。根据患者的HAARTpy，H