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时间:2020-04-20
《两种 HAART 方案对 HIV/AIDS患者血脂的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、2574重庆医学2014年7月第43卷第2O期论著·临床研究doi:10.3969/i.issn.16718348.2014.20.011两种HAART方案对HIV/AIDS患者血脂的影响李虹,陈媛媛,何云,李超锋,刘春礼,孙燕,赵清霞A(河南省郑州市第六人民医院感染科450015)摘要:目的观察两种高效抗逆转录病毒治疗(HAART)方案应用48周对HIV/AIDS患者血脂的影响。方法将102例HIV/AIDS患者根据不同的HAART方案分为司他夫定(D4T)组[D4T联合拉米夫定(3TC)及奈韦拉平(NVP)治疗]
2、和齐多夫定(AZT)组(AZT联合3TC及NVP治疗)。检测基线及HAART后24、48周时的三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL—C)水平。结果配对t检验分析,D4T组患者24周TG、TC和LDL-C均显著升高(P0.05)。结论包含D4T和AZT的HAART方案均可导致HIV/AID
3、s患者血脂异常,主要是TG和TC升高,均以边缘升高为主。应用包含D4T的方案的HIV/AIDs患者TG和TC升高较早,并且TC升高后持续保持在较高的水平。关键词:抗逆转录病毒治疗,高效;获得性免疫缺陷综合征;HIV;血脂中图分类号:R512.91文献标识码:A文章编号:167卜8348(2014)20—2574—03TheimpacttobloodlipidinpatientswithHIV/AIDSusingtwodifferentHAARTregimensLiHong,ChenYuanyuan,HeYun,LiC
4、haofeng,LiuChunli,SunYah,ZhaoQingxia(InfectiousDiseases,theSixthPeopleHospitalofZhengzhouCity,Zhengzhou,Hennan450015,China)Abstract:0bjectiveTounderstandtheimpacttobloodlipidinpatientswithHIV/AIDSusingdifferentHAARTregimens.MethodsAccordingtoHAARTregimens,102HI
5、V/AIDSpatientsweredividedintotwogroups:D4Tgroup(D4T+3TC+NVP)andAZTgroup(AZT+3TC+NVP).Bloodlipids(TG,TC,I.DI.-CandHDL-C)atbaseline,24weeksand48weeksafterHAARTweredetected.ResultsComparedwithpairedttest,TG,TCandLDL-Cat24weeksfollow-upofthepatientsinD4Tgroupweresi
6、gnificantlyhigherthanatbaseline(P~0.05),andTCat48weeksfollowupwerestillhigherthanatbaseline(P<0.05).TGandTCat24weeksfollow—upofpatientsinAZTgroupweresignificantlyhigherthanatbaseline(P~0.05).Therewerenosignificantdifferenceatbloodlipidbetweenthetwogroups(P>0.05
7、).ConclusionTherearedyslipidemiaofthepatientswithHIV/AIDSu—singD4T—basedandAZT-basedregimens.andthedyslipidemiaareincreaseofTCandTG,theseincreaseisborderhigher.TGandTCat24weeksfollow-upoftheHIV/AIDSpatientsusingD4T—basedregimenareincreasedearly,andTCarestillath
8、igherleve1.Keywords:antiretroviraltherapy,highlyactive;acquiredimmunodefieiencysyndrome;HIV;lipids高效抗逆转录病毒治疗(highlyactiveantiretroviralthera—经疾病者;依从性差,无法保证随访者。根据患者的HAARTpy,H
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