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1、TNF-a及IL-6在重症急性胰腺炎患者血清中变化及临床意义［摘要］目的探讨TNF-a和IL-6在重症急性胰腺炎(SAP)患者血清中的动态变化及临床意义。方法选取2001年10月〜2010年7月入住我院的急性胰腺炎患者60例，按照病情程度分为SAP组、轻症急性胰腺炎(MAP)组，每组30例，同时将健康体检者30例作为空白对照组，用ELISA法分别检测三组入院第1天、第3天、第7天、第14天血清TNF-a.IL-6的水平，结果进行统计学分析。结果入院时SAP组TNF-a水平［(59.6±14.7)pg/mL］显著髙于MAP组［(38.
2、3±9.1)pg/mL］和空白对照组［(13.8±4.3)pg/mL］(P<0.05),MAP组患者血清TNF-a水平也较空白对照组显著升高(P<0.05),但IL-6水平$人卩组［(45.8±11.2)pg/mL］和MAP组［(42.9土12.9)pg/mL］均较空白对照组［(38.9±10.9)pg/mL］无明显升高(P>0.05)；SAP组血清IL-6在入院的第7天升高最明显［(190.1土49.9)pg/mL］,分别高于MAP组［(113.9±28.1)pg/mL］和空白对照组(P<0.05),MAP组亦明显高于空白对照组(
3、P<0.05)；在入院第14天SAP组血清TNF-a［(36.8±7.1)pg/mL］.IL-6［(113.1土24.7)pg/mL］仍然高于MAP组［(14.8±3.3)、(43.6±12.8)pg/mL］和空白对照组(P<0.05),而MAP组与空白对照组比较差异无统计学意义(P>0.05)o结论重症急性胰腺炎患者治疗前后血清TNF-a和IL-6的水平变化，可以作为对该病的早期诊断、病情判断和预后评估的依据之一，具有重要的临床应用价值。［关键词］重症急性胰腺炎；肿瘤坏死因子-a；白细胞介素-6［中图分类号］R576［文献标识码］
4、C［文章编号］1673-7210(2012)07(a)-0157-02DynamicchangesandclinicalsignificanceofserumTNF-aandIL-6insevereacutepancreatitisZHONGHongSHIYongLIGuanqiangDepartmentofGeneralSurgery,LonggangDistrietPeople"sHospitalinShenzhenCity,GuangdongProvince,Shenzhen518172,China［Abstract］Obje
5、ctiveToinvestigatethedynamicchangesandclinicalsignificanceofserumTNF-aandIL~6insevereacutepancreatitis(SAP)・Methods60caseswhoareadmittedtoourhospitalwithacutepancreatitisfromOctober2001toJuly2010wereselectedanddividedintomildacutepancreatitis(MAP)groupandsevereacutepan
6、creatitis(SAP)groupwiththestandardofseverity,with30casesineachgroup,atthesametime30casesofhealthypersonswereascontrolgroup,ELISAmethodwasusedtodetecttheserumTNF-alpha,IL~6levelsofthreegroupsofhospitalizedoneday,threedays,sevendays,fourteendays,theresuItswerestatistical
7、lyanalyzed・ResuItsThelevelsofTNF-ainSAPgroup[(59.6+14.7)pg/mL]weresignificantlyhigherthanthoseinMAPgroup[(38.3+9.1)pg/mL](P<0.05)andcontrolgroup[(13.8土4.3)pg/mL]andthelevelsofTNF-ainMAPgroupweresignificantlyhigherthancontrolgroup(P<0.05),butthelevelsofIL~6werenotsignif
8、icantlydifferentamongthethreegroupsonadmission[(45.8±11.2)pg/mL,(42.9±12.9)pg/mL,(38.9±10.9)pg/mL](P>0.05).Thelevelso
