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1、醒脑静注射液联合盐酸纳洛酮注射液治疗脑出血伴昏迷患者的临床疗效[摘耍]目的研究醒脑静注射液联合盐酸纳洛酮注射液治疗脑出血伴昏迷病患的临床疗效。方法整群选取该院2013年11月一2015年1月住院接受治疗的83例脑出血伴昏迷病患。病患分组方法:密封信封随机分组。83例病患分为组&和组b两个组别。组a4mg盐酸纳洛酮注射液+250mL5%葡萄糖静滴,1次/d,用药2周;组b4mg盐酸纳洛酮注射液+250mL5%葡萄糖静滴,20mL醒脑静注射液+250mL5%葡萄糖静滴,均1天1次,用药2周。观察指标:①总有效率;②药物副作用;③用药前后
2、病患神经功能缺损评分、认知评分、昏迷评分、血肿量的差异;④昏迷时间。结果组b总有效率95.24%相比于组a75.61%总有效率更高,神经功能缺损评分、认知评分、昏迷评分、血肿量改善更显著,差异有统计学意义P0.05;组b昏迷时间(5.51±2.41)h比a(8.39±2.77)h更短,差异有统计学意义P<0.05o结论醒脑静注射液联合盐酸纳洛酮注射液治疗脑出血伴昏迷病患的临床疗效确切,可有效促醒,减少血肿,改善病患认知功能和神经功能,安全性高,值得推广。[关键词]醒脑静注射液;盐酸纳洛酮注射液;脑出血伴昏迷病患;临床疗效[中图分类号
3、]R743.34[文献标识码]A[文章编号]1674-0742(2016)06(a)-0138-03[Abstract]ObjectiveStudyofXingnaojinginjectioncombinedwithhydrochloridenaloxoneinjectioninthetreatmentofcerebralhemorrhagewithcomapatientclinicalcurativeeffect.MethodsGroupseiection83casesofcerebralhemorrhagewithcomapat
4、ientsadmittedinourhospitalfromNovember2013-2015toJanuary.Patientgroupingmethod:randomgroupingofsealedenvelopes.83patientsweredividedintogroupaandgroupbintwogroups.Groupa4mgnaloxonehydrochlorideinjection+250mL5%glucoseintravenous,1times1day,2weeksofmedication;intravenou
5、sdripofgroupb4mgnaloxonehydrochlorideinjection+250mL5%glucose,20mlXingnaojinginjection+250mL5%glucoseintravenous,1day1times,medication2weeks.Observationindex:①thetotaleffectiverate;②drugsideeffects;③beforeandafterthetreatmentofpatientswithneurologicaldeficitscores,cogn
6、itivescore,comascore,thedifferencebetweentheamountofhematoma;@comatime.ResultsGroupbtotaleffectiverateis95.24%comparedtoagroupa75.61%totalefficiencyismorehigh,neuralfunctiondefectscore,cognitivescore,coinascore,hematomavolumeimprovedmoresignificantly,thedifferenceofthe
7、wasstaticallysignificantP0.05;comatimeinBgroup(5.51±2.41)hthana(8.39+2.77)hshorter,thedifferenceofthewasstaticallysignificant卩〈0.05.ConclusionXingnaojinginject!onhydrochloridecombinedwithnaloxoneinjectioninthetreatment,ofcerebralhemorrhagecomplicatedwithcomapatientclin
8、icalcurativeeffect,caneffectivelypromotewakeup,reducehematoma,improvethecognitivefunctionandneuralfunctionofthepatien