莫西沙星联合哌拉西林钠他唑巴坦钠治疗重症肺炎临床疗效观察.doc

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1、莫西沙星联合哌拉西林钠他睦巴坦钠治疗重症肺炎临床疗效观察［摘要］目的观察莫西沙星联合哌拉西林钠他哇巴坦钠治疗重症肺炎临床疗效。方法选取2010年2月〜2012年2月在我院治疗的重症肺炎患者80例随机分为两组。治疗组给予静脉滴注莫西沙星400mg/d加哌拉西林钠他哇巴坦钠13.5g/d,对照组给予静脉滴注左氧氟沙星400mg/d加哌拉西林钠他哩巴坦钠13.5g/d,两组使用相同常规治疗主要为机械通气、祛痰、解痉等视病情给予强心、利尿等对症及氨基酸、白蛋白等支持治疗，两组均治疗10〜14d观察疗效。结果治疗组在发热消失、痰液颜色改变、血常规恢

2、复正常、机械通气、胸部影像明显吸收方面改善所需要的时间相比对照组短，差异有统计学意义；治疗组在白细胞、血气、肝肾功能指标显著好于对照组；治疗组的总有效率明显优于对照组。结论莫西沙星联合哌拉西林钠他哇巴坦钠治疗重症肺炎疗效显著，值得临床推广。［关键词］莫西沙星；哌拉西林钠他11坐巴坦钠；重症肺炎［中图分类号］R969.4；R563.1［文献标识码］B［文章编号］1673—9701(2012)26—0066—02Clinicalobservationofseverepneumoniatreatedwithmoxifloxacinhydroch

3、loridecombinedwithpiperacillinsodiumandtazobactamsodiumforinjectionXIAOXiaorongICU,theFirstPeople，sHospitalofTaizhouCityinZhejiangProvince,Taizhou318020,China[Abstract]ObjectiveToevaluatetheclinicaleffectofmoxifloxacinhydrochloridecombinedwithpiperacillinsodiumandtazobact

4、ainsodiumforinjectiontreatmentonseverepneumonia・MethodsSelected80severepneumoniapatientstreatedinourhospitalfromFebruary2010toFebruary2012divideinto2groupsrandomly.ThetreatmentgroupwasprovidedwithintravenousdripMoxifloxacin400mg/dandTazobactamSodium/Piperaci11inSodium13.5

5、g/d.ThecontrolgroupwasprovidedwithintravenousdripLevofloxacin400mg/dandTazobactamSodium/Piperaci11inSodium13.5g/d・Bothgroupswereprovidedwiththesameconventionaltreatment，mainlyincludingmechanicalventilation,eliminatingphlegmandspasmolysis,etc.,andsymptomatictreatmentsuchas

6、cardiacanddiuresisandsupportingtherapysuchasaminoacidandalbumin.Thecurativeeffectsinbothgroupswereobservedafter10一14daystreatment・ResultsAftertreatment,thetimeforthetreatmentgrouptoimproveinfiveaspectssuchasfeverdisappearance,sputumcolorchange,bloodroutinereturningtonorma

7、l，mechanicalventilationandobviousabsorptionofchestimagingisshorterthanthatforthecontrolgroup,whichhadasignificantdifference；aftertreatment,leukocyte，bloodgasandhepatorenalfunctionalindexesofthetreatmentgroupwereparticularlybetterthanthoseofthecontrolgroup；theoveralleffici

8、encyofthetreatmentgroupwasobviouslyhigherthanthatofthecontrolgroup.ConclusionMoxifloxacinhydroch