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时间:2020-04-19
《急性脑梗死患者血清胱抑素C与同型半胱氨酸及颈动脉内膜中层厚度的相关性探讨.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、疑难病杂志2014年8月第l3卷第8期ChinJDificandComplCas,August2014.Vo1.13No.8·793·急性脑梗死患者血清胱抑素C与同型半胱氨酸及颈动脉内膜中层厚度的相关性探讨冯敏,焦贤春,沈龙山基金项目:蚌埠医学院科研课题资助项目(No.Byky1255)作者单位:233040蚌埠医学院第二附属医院神经内科(冯敏),检验科(焦贤春),放射科(沈龙山)【摘要】目的探讨急性脑梗死(ACI)患者血清胱抑素C(CysC)水平与血同型半胱氨酸(Hcy)以及颈动脉粥样硬化(CAA)的相关性。方法选择120例脑梗死
2、患者为观察组,同期住院非脑血管疾病患者60例为对照组。检测并比较2组血清CysC、三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL—C)、高密度脂蛋白胆固醇(HDL.c)、空腹血糖(FPG)、Hcy水平,以及应用彩色多普勒超声检测其颈动脉内膜中层厚度(IMT)。结果观察组和对照组血清CysC水平分别为(1.36±0.24)mg/L和(1.03±0.13)mg/L,2组比较差异有统计学意义(P<0.01);2组TG、TC、LDL-C、HDL-C、FPG、Hcy水平及颈动脉IMT比较差异亦均有统计学意义(P<0.01)。血清
3、CysC水平与Tc、TG、HDL-C、LDL-C、FPG均无相关性(r=0.076、一0.158、一0.040、0.012、一0.176,P均>0.05),而与血Hcy及颈动脉IMT均呈显著正相关(r=0.871、0.819,P均<0.01)。结论高CysC血症是脑梗死重要危险因素,与血Hcy呈正相关,且与颈动脉粥样硬化的形成密切相关。【关键词】脑梗死,急性;胱抑素C;同型半胱氨酸;颈动脉粥样硬化【DOI】10.3969/j.issn.1671-6450.2014.08.008RelationshipofserumCys-C.hom
4、ocysteinelevelandintima-mediathicknessincarotidarteryatherosclerosiswitha-cutecerebralinfarctionFENGMin,JIAOXianchun,SHENLongshan.DepartmentofNeurology,theSecondAffiliatedHospitalofBengbuMedicalCollege,AnhuiProvince,Bengbu233040,China【Abstract】ObjectiveToinvestigatethe
5、correlationofselMmcystatinC(Cys-C),thelevelofplasmahomocysteine(Hcy)andcarotidatherosclerosis(CAA)inacutecerebralinfarction(ACI)patients:MethodsOnehundredandtwentyeasesofcerebraljmCaretionpatientswereenrolledasobservationgroup.inthesameperiod.6Ocasesofnoncerebrovascula
6、rdiseasepatientswereenrolledasacontrolgroup.TheseYumCys—C,threeglycerol(TG),cholesterol(TC),lowdensitylipo—proteincholesterol(LDL-C),highdensitylipoproteincholesterol(HDL—C),fastingblooducose(FPG),Hcylevelsofthe2groupsweredetectedandcompared,aswellasusedthecolorDoppler
7、ultrasoundtodetectthecarotidarteryintima—mediathick—ness(IMT).ResultsTheobservationgroupandthecontrolgroupofserumCys—Cwere(1.36±0.24)mg/Land(1.03±0.13)mg/L,therewassignificantdifferencebetweenthe2groups(P<0.01);TG,TC,LDL-C,HDL·C,FPG,HcylevelandcarotidarteryIMTweresigni
8、ficantdifferentbetweenthe2groups(P<0.01).SerumCys—ClevelandTC,TG,HDL—C,LDL—C,FPGarenotcorrelated(r=0.076,一0.158,一0.04
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