病理生理英文课件2

《病理生理英文课件2》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、DIC1OUTLINEOUTLINEReviewsReviewsConceptofDICConceptofDICCausesandpathogenesisCausesandpathogenesisFactorsinfluencingDICdevelopmentFactorsinfluencingDICdevelopmentStagesandclassificationStagesandclassificationFunctionandmetabolismchangesFunctionandmetabolismchangesManagementandpreventionManag

2、ementandprevention2reviewsHomeostasisamongcoagulation,anticoagultion&fibrinolysissystemCoagulationsystemAnticoagultionsystem••Intrinsic••Cellular••ExtrinsicMono-phagocyteLivercellsEpithelium••BodyfluidPlasma(AT-Ⅲ，TFPI)ProteinC(PC)ProteinS(PS)fibrinolyticsystemTissuetype,urokinaset-PAFIXa,X

3、IIa,plasminogenactivator-酶原激活物3u-PAKallikrein,FDPreviewsHemostaticBalanceHemostaticBalancePAI-1Prot.SAntiplasminProt.CTFPITissuefactor*FibrinolyticSystemClottingFactorsAT-IIIProcoagulantAnticoagulant4reviews内源性途径外源性途径IntrinsicpathwayExtrinsicpathwaysurfacecontactTissuedamageXIIXIIaclottingcascadeX

4、IXIaPF3Ca+-PL2IXaIX■Ⅲ组织因子Tissuefactor(Ⅲ)VIIIaVIIa2+XaCaCa2+Va(凝血酶原激活物)PF3■Ca2+XXIII凝血酶PF3Thrombin■凝血酶原■凝血酶ProthrombinThrombin纤溶酶原XIIIa纤溶酶plasminogen2+■plasminCa,XIIIaStable纤维蛋白单体纤维蛋白降解纤维蛋白原FibrinclotFibrinmonomer产物FDPFibrinogen5■:inhibitingsitesofAT-ⅢreviewsPhysiologicPhysiologicHemostasisHemostasi

5、sBloodVessleinjuryNerveTissueFactorAggregationCoagulationvasoconstrictionofPLTcascadeprimaryhemostaticplugPLTactivationFibrinBloodflow↓formationStableHemostaticPlugHemostasisHemostasis6HomeastasisHomeastasisreviewsCONGENITALCLOTTINGDISORDERSCONGENITALCLOTTINGDISORDERSVonWillebranddiseaseVonWillebr

6、anddisease••Incidence0.6-2%ofpopulationHemophiliaHemophilia••Incidence20/100,000males••85%HemophiliaA(factorⅧ)X-linkedrecessive••15%HemophiliaB(factorⅨ)Autosomal••HemophiliaC(factorⅪ)recessive••Mostseriousbleedingdisorder7reviewsHEMOPHILIAHEMOPHILIASexSex––linkedrecessivediseaselinkedrecessivedis

7、easeDiseasedates:6monthDiseasedates:6month--Incidence:20/100,000malesIncidence:20/100,000malesClinicallyindistinguishableexceptbyClinicallyindistinguishableexceptbyfactoranalysisfactoranalysisGeneticlet