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1、PotassiumBalanceandPotassiumImbalancePartⅠPotassiumBalanceⅠContentandDistributionofPotassiumintheBodyⅡIntakeandExcretionofPotassiumDietaryKintake70~100mmol/dayECF2%Serum[K+]round4.5mmol/LK+SkintrivialnormallyColon10%Kidneys>80%Moreingested,moreexcreted
2、Lessingested,lessexcretedNotingested,excretiongoesonContent,distribution,intakeandexcretionofKExcretionICF[K+]160mmol/L98%ofthetotalbodypotassiumTotalbodyKcontent31~57mmol/KgbodyweightⅢMaintenanceofPotassiumHomeostasis—DistributionofK+acrossthecellmemb
3、raneandRegulationofrenalK+excretion1.Hormones—insulin,glucagon,catecholamines,thyroidhormone2.Serum[K+]3.pHofECFandplasmaosmolality4.Others—rateofcellbreakdown,hypoxia,hypothermia,exerciseInfluencingFactors[K+]↑Na+Na+/K+-ATPaseK+K+H+CatecholamineInsuli
4、nRegulationofRenalPotassiumExcretionFiltration,reabsorptionandsecretionofpotassiumThenephronandcollectingtubuleCl-Na+/K+ATPase(Mg2+activated)Na+/K+ATPaseH+-K+ATPaseAfferentEfferentarterioleBowman’scapsuleglomerulusProximaltubuleReabsorptionGlucoseSodiu
5、mWaterBicarbonate(HCO3-)Henle’sloop(thickandthinsegment)PrimerUrine180L/day(ultrafiltrate)JuxtaglomerularcellsReninAngiotensinIIIIIIAldosterone(Adrenalcortex)RAAS(+)MaculadensaReabsorptionSodium>WaterdiluteReabsorptionWater>SodiumExchangeofionHydrogen-
6、SodiumPotassium-SodiumReabsorbwaterADHcanincreasethepermeabilityofthetubularmembranewallstoreabsorbmorewater.CollectingtubulecondenseUrine1.5~2.0L/dayAdlosteronecanenhancetheexchangeofpotassium-sodium(increasesthereabsorptionofsodium)(enhancestheexcret
7、ionofpotassium)(1)Reabsorbsodium(water)andexcretepotassium.(2)ExcretehydrogenandreabsorbbicarbonateDistalconvolutedtubuleRegulationofRenalPotassiumExcretionFiltration,reabsorptionandsecretionofpotassiumSecretionofpotassiuminthedistalandcollectingtubule
8、sprincipalcells,withNa+/K+ATPasemembranepump,forsecretionofK+lumenPrincipalCellbloodK+Na+Na+K+Cl-Cl-K+CO2HCO3-Cl-Cl-H+K+CO2IntercalatedCellRegulationofRenalPotassiumExcretionFiltration,reabsorptionandsecretionofpotassiumSecretionofpotas
