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时间:2017-12-08
《嗅鞘细胞条件培养液和星形胶质细胞条件培养液对受损海马神经元保护作用的对比研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、神经损伤与功能重建·2010年9月·第5卷·第5期325·[DOll10.3870/sjsscj.2010.05.003论著·嗅鞘细胞条件培养液和星形胶质细胞条件培养液对受损海马神经元保护作用的对比研究张华军,徐格林●刘新峰#1.南京大学医学院附属鼓楼医院中西医结合科,南京210008;2.南京军区南京总医院神经内科,南京210002【摘要】目的:观察嗅鞘细胞条件培养液(OECCM)和星形胶质细胞条件培养液(ACM)对受损海马神经元的保护作用。方法:分别采用2种胶质细胞条件培养液预处理受损海马神经元(谷氨酸诱导损
2、伤),对比其对受损海马神经元活力、凋亡率和胞浆内游离钙离子浓度的影响。结果:与谷氨酸组相比,OECCM组神经元活力明显增高(P<0.01),ACM组神经元活力增高(P3、CM的保护作用优于ACM。【关键词】嗅鞘细胞;星形胶质细胞;条件培养液;神经保护【中图分类号】R741;R741.02【文献标识码】A【文章编号】1001117X(2010)05—032505AComparativeStudyofNeuroprotecti0nEffectsofOlfactoryEnsheathingCellsConditionedMediumandAstrocytesConditionedMediumonHippocampaiNeuronalInjuryZHANGHua—Hn▲,XUGe—lin4、,LIUXin—feng.‘DepartmentofIntegratedTraditionalChineseandWesternMeaicine.NanjingDrumTowerHospital,Nanjing210008,China[Abstract]Objective:Toevaluatetheneuroprotectioneffectsofolfactoryensheathingce11sconditionedmediumfOECCM)andastrocytesconditionedmedium(ACM)o5、ninjuredhippocam—palneurons.Methods:HippocampalneuronswhichwereindividuallypretreatedbyACMorOECCMhavebeeninjuredbyglutamate.Neuronalviability,apoptosisrateandintracellu1arfreecalciumconcentrationhavebeenmeasured.Results:Comparedwiththatintheglutamategroup,the6、neuronalviabilityofneuronspretreatedeitherbyOECCMorbyACM,waSincreasedandtheapoptosisrateandintracellularfreecalciumconcentrationwerereduced.However,theneuronvi—abilityinOECCMgroupwashigherthanthatinACMgroupandtheapoptosisrateandintrace1lularfreecalciumconcent7、rationwere1owerthanthatinACMgroup.Conclusion:OECCMandACMpretreatmentcouldremarkablyincreasetheviabilityandredUcetheapoptosisrateandtheintracellularfreecalciumconcentrationofinjuredhippocampalneuronsandOECCMcouldDr。videamorepromisingconditionforneurons.[Keywor8、ds]olfactoryensheathingcells;astrocytes;conditionedmedium;neuroprotection神经元是中枢神经系统(centralnetvous作为另一种细胞类型,在神经元的生长发育system,CNS)基本结构单位,神经胶质细胞和修复过程中发挥重要作用。星形胶质细胞(astrocytes,ACs)是哺乳动物CNS内分布
3、CM的保护作用优于ACM。【关键词】嗅鞘细胞;星形胶质细胞;条件培养液;神经保护【中图分类号】R741;R741.02【文献标识码】A【文章编号】1001117X(2010)05—032505AComparativeStudyofNeuroprotecti0nEffectsofOlfactoryEnsheathingCellsConditionedMediumandAstrocytesConditionedMediumonHippocampaiNeuronalInjuryZHANGHua—Hn▲,XUGe—lin
4、,LIUXin—feng.‘DepartmentofIntegratedTraditionalChineseandWesternMeaicine.NanjingDrumTowerHospital,Nanjing210008,China[Abstract]Objective:Toevaluatetheneuroprotectioneffectsofolfactoryensheathingce11sconditionedmediumfOECCM)andastrocytesconditionedmedium(ACM)o
5、ninjuredhippocam—palneurons.Methods:HippocampalneuronswhichwereindividuallypretreatedbyACMorOECCMhavebeeninjuredbyglutamate.Neuronalviability,apoptosisrateandintracellu1arfreecalciumconcentrationhavebeenmeasured.Results:Comparedwiththatintheglutamategroup,the
6、neuronalviabilityofneuronspretreatedeitherbyOECCMorbyACM,waSincreasedandtheapoptosisrateandintracellularfreecalciumconcentrationwerereduced.However,theneuronvi—abilityinOECCMgroupwashigherthanthatinACMgroupandtheapoptosisrateandintrace1lularfreecalciumconcent
7、rationwere1owerthanthatinACMgroup.Conclusion:OECCMandACMpretreatmentcouldremarkablyincreasetheviabilityandredUcetheapoptosisrateandtheintracellularfreecalciumconcentrationofinjuredhippocampalneuronsandOECCMcouldDr。videamorepromisingconditionforneurons.[Keywor
8、ds]olfactoryensheathingcells;astrocytes;conditionedmedium;neuroprotection神经元是中枢神经系统(centralnetvous作为另一种细胞类型,在神经元的生长发育system,CNS)基本结构单位,神经胶质细胞和修复过程中发挥重要作用。星形胶质细胞(astrocytes,ACs)是哺乳动物CNS内分布
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