阿托伐他汀钙对动脉粥样硬化大鼠血脂水平及crp-mrna表达的影响

《阿托伐他汀钙对动脉粥样硬化大鼠血脂水平及crp-mrna表达的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、·实验研究·2013年l2月第20卷第36期阿托伐他汀钙对动脉粥样硬化大鼠血脂水平及CRP-mRNA表达的影响高招波魏晓琴郑春华肖冬平南昌市第一医院心血管科，南昌330006【摘要】目的探讨阿托伐他汀钙对动脉粥样硬化(As)大鼠血脂水平及CRP—mRNA表达的影响。方法选取45只健康雄性大鼠随机分为3组，对照组喂食基础饲料，AS模型组、观察组均喂食高脂饲料，4周后观察组给予阿托伐他汀钙灌胃，8周后测量所有大鼠的低密度、高密度脂蛋白胆固醇(LDL—C、HDL—C)和CRP—mRNA表达水平。结果观察组的LDL—C

2、明显低于对照组和AS模型组，HDL—C明显高于对照组和AS模型组，差异有统计学意义(P<0．05)。AS模型组的LDL—C明显高于对照组，HDL—C明显低于对照组，差异有统计学意义(P<0．05)。观察组的CRP—mRNA表达水平明显低于AS模型组，差异有统计学意义(P<0．05)。结论阿托伐他汀钙能明显降低AS大鼠的LDL～C，升高HDL—C，抑制AS段CRP—mRNA表达，从而延缓AS的进程。f关键词】阿托伐他汀钙；动脉粥样硬化；大鼠；低密度脂蛋白胆固醇；CRP—mRNA表达f中图分类号】R543『文献标识

3、码】A『文章编号11674—4721l2013)12(c)-0034—02InfluenceofatorvastatincalciumonlipidlevelandCRP—mRNAexpres．sionofratwithatherosclerosisGA0Zhao-boWEIXiao-qinZHENGChun—huaXIA0Dong-pingDepartmentofCardiovascular，theFirstHospitalinNanchangCity，Nanchang330006，China【Abstrac

4、t】ObjectiveToexploreinfluenceofatorvastatincalciumonlipidlevelandCRP-mRNAexpressionofratwithatherosclerosis(AS)．Methods45healthymaleratswereselectedandrandomlyassignedtothreegroups．Controlgroupwasgivenbasicfood，ASmodelgroupandobservationgroupweregivenfoodwit

5、hhighfat．Fourweekslater，ob-servationgroupwasforcedtobegivenatorvastatincalcium．Eightweekslater，thelevelofLDL-C，HDL-CandCRP-mRNAexpressionweremeasured．ResultsLDL-ClevelofobservationgroupwassignificantlylowerthanthatofcontrolgroupandASmodelgroup，HDL-Clevelofob

6、servationgroupwassignificantlyhigherthanthatofcontrolgroupandASmodelgroup，withstatisticaldifference(P<0．05)．LDL—ClevelofASmodelgroupwassignificantlyhigherthanthatofcontrolgroup，HDL-ClevelofASmodelgroupwassignificantlylowerthanthatofcontrolgroup，withstatistic

7、aldiffer—ence(P<0．05)．CRP—mRNAexpressionlevelofASmodelgroupwassignificantlyhigherthanthatofcontrolgroup，withstatisticaldifference(P<0．05)．ConclusionAtorvastatincalciumcansignificantlylowerLDL-CleveloftheratwithAS，increaseHDL-ClevelandinhibitCRP—mRNAexpressio

8、nofAS，whichhelpdelayprogressofAS．【Keywords】Atorvastatincalcium；Atherosclerosis；Rat；LDL—C；CRP—mRNAexpression动脉粥样硬化(atherosclerosis，AS)可致动脉管壁增厚、益医药原料有限公司：低分子量标准蛋白购自中科院上海变硬、管腔狭窄等，直接引发多种心脑血管事件的发生_lJ