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时间:2017-12-07
《舒芬太尼和芬太尼用于神经外科手术麻醉的比较研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、436·中困现代神经疾病杂志2010年8月第lo卷第4期ChinJContempNeurolNeurosurg,Aug!,!!:!!:!.论著·舒芬太尼和芬太尼用于神经外科手术麻醉的比较研究焦晶华陈晓光马虹【摘要】目的观察全身麻醉药物舒芬太尼和芬太尼对中枢神经系统肿瘤切除术患者围手术期血流动力学、苏醒期恢复情况及机体应激反应的影响。方法50例择期行中枢神经系统肿瘤切除术患者,随机接受舒芬太尼和芬太尼全身麻醉,观察并记录麻醉诱导后、插管后lmin、头架固定时、切开皮肤、切开硬脑膜、关闭硬脑膜、恢复呼吸即刻和拔管
2、即刻等不同观察时间点平均动脉压、心率、脉搏血氧饱和度等项指标的变化,测定麻醉诱导前后血糖和肾上腺素水平。结果与基础值相比,两组患者在切开硬脑膜、恢复呼吸即刻和拨管即刻心率增加(均P3、手术前、切开皮肤3Omin、拔管即刻血糖和肾上腺素水平比较,差异无统计学意义(均P>0.05)。结论与芬太尼组比较,舒芬太尼组患者在不同麻醉时期血流动力学更稳定,气管插管时心血管反应更小;舒芬太尼和芬太尼对患者围手术期血糖和肾上腺素均无明显影响。【关键词】舒芬太尼;芬太尼;麻醉,全身;神经外科手术;血流动力学DOI:l0.3969/j.issn.1672—6731.20l0.O4.0l0Comparativestudyofsufentanilandfentanylforanesthesiainneurosur4、gicaiprocedureJIA0Jing-hua,CHENXiao—guang,MAHong.DepartmentofAaesthesiology,theFirstHospitalofChinaMedicalUniversity,Shenyang110001,Liaoning,ChinaCorrespondingauthor:CHENXiao—guangfEmail:chxg2OOO@yahoo.corn)【Abstract】0bjectiveTocomparetheefectsofsufentanila5、ndfentanylasgeneralanesthesiaonhemodynamics,recoveryprofilesandthestressreactionatperioperativeperiodinpatientsundergoingintracranialtumorresection.MethodsAtotalof50patientsscheduledwererandomizedtoreceivesufentanil(groupS,n=25)orfentanyl(groupF,n=25)asgene6、ralanesthesiaforintracranialtumorresection.SufentanilwasperformedingroupSbycombinationofintravenouspropofolandsevofluraneanesthesia,whilefentanylpluspropofolcontinuousintravenousinfusionwasusedingroupFfollowedbysevofluraneanesthesia.Thepatientsmeanarterialp7、ressure(MAP),heartrate(HR)andpulseoxygensaturation(SpO2)werecontinuouslymonitoredandrecordedatdiferenttimepointsincludingbaseline(To),postanesthesiainduction(T1),1minafterendotrachealintubation(T2),headholderapplication(T3),skinandduralincisions(T4,T5),dura8、lclosure(T6),spontaneousbreathrecovery(T7)andafterendotrachealextubation(T8).Bloodglucoseandepinephrineweredeterminedbeforeandafteranesthesiainduction.ResultsInbothgroups,theHRatT5,T7andwerehigherthanb
3、手术前、切开皮肤3Omin、拔管即刻血糖和肾上腺素水平比较,差异无统计学意义(均P>0.05)。结论与芬太尼组比较,舒芬太尼组患者在不同麻醉时期血流动力学更稳定,气管插管时心血管反应更小;舒芬太尼和芬太尼对患者围手术期血糖和肾上腺素均无明显影响。【关键词】舒芬太尼;芬太尼;麻醉,全身;神经外科手术;血流动力学DOI:l0.3969/j.issn.1672—6731.20l0.O4.0l0Comparativestudyofsufentanilandfentanylforanesthesiainneurosur
4、gicaiprocedureJIA0Jing-hua,CHENXiao—guang,MAHong.DepartmentofAaesthesiology,theFirstHospitalofChinaMedicalUniversity,Shenyang110001,Liaoning,ChinaCorrespondingauthor:CHENXiao—guangfEmail:chxg2OOO@yahoo.corn)【Abstract】0bjectiveTocomparetheefectsofsufentanila
5、ndfentanylasgeneralanesthesiaonhemodynamics,recoveryprofilesandthestressreactionatperioperativeperiodinpatientsundergoingintracranialtumorresection.MethodsAtotalof50patientsscheduledwererandomizedtoreceivesufentanil(groupS,n=25)orfentanyl(groupF,n=25)asgene
6、ralanesthesiaforintracranialtumorresection.SufentanilwasperformedingroupSbycombinationofintravenouspropofolandsevofluraneanesthesia,whilefentanylpluspropofolcontinuousintravenousinfusionwasusedingroupFfollowedbysevofluraneanesthesia.Thepatientsmeanarterialp
7、ressure(MAP),heartrate(HR)andpulseoxygensaturation(SpO2)werecontinuouslymonitoredandrecordedatdiferenttimepointsincludingbaseline(To),postanesthesiainduction(T1),1minafterendotrachealintubation(T2),headholderapplication(T3),skinandduralincisions(T4,T5),dura
8、lclosure(T6),spontaneousbreathrecovery(T7)andafterendotrachealextubation(T8).Bloodglucoseandepinephrineweredeterminedbeforeandafteranesthesiainduction.ResultsInbothgroups,theHRatT5,T7andwerehigherthanb
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