急性脑梗死外周血中 NOX2、SOD 水平变化的临床意义-论文.pdf

《急性脑梗死外周血中 NOX2、SOD 水平变化的临床意义-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、第37卷第3期右江民族医学院学报Vo1．37No．32015年6月JournalofYoujiangMedicalUniversityforNationalitiesJun．2015急性脑梗死外周血中NOX2、SOD水平变化的临床意义朱菁锋。张健生。黎志锵，李天宝。张家济，薛光华(广东省佛山市南海区第九人民医院神经内科，广东佛山528203)摘要：目的探讨外周血NOX2、SOD水平与急性脑梗死的关系。方法收集98例急性脑梗死患者，采用ELISA法以及wST一1还原法分别测定急性脑梗死患者患病后24h、3d、7d、14d以及对照组SoD、N0X2在外周血的水平

2、，并与91例健康者进行比较。结果脑梗死组外周血SOD值表达于发病后24h内降低显著多于对照组(P0．05)；脑梗死组NOX2在发病后24h即明显升高(P

3、着动态变化，与脑梗死的严重程度有关，其浓度水平对急性脑梗死的病情变化及治疗具有重要的价值。关键词：NOX2；SOD；脑梗死中图分类号：R743．33文献标识码：A文章编号：1001—5817(2015)03—0373—03doi：10．3969／j．issn．1001—5817．2015．03．010ClinicalsignificanceofperipheralbloodNOX2，SODchangesinacutecerebralinfarctionZhuJingfeng，ZhangJiansheng，LiZhiqiang，LiTianbao，ZhangJ

4、iaji，XueGuanghua(DepartmentofNeurology，theNinthPeople~HospitalofNanhaiDistrict，Foshan528203，Guangdong，China)Abstract：ObjectiveToexploretherelationshipofacutecerebralinfarctionandperipheralbloodNOX2andSODlevels．MethodsNinety—eightcasesofacutecerebralinfarctionpatientswereselectedast

5、heob—servationgroup，and91casesofhealthyindividuals(inphysicalexamination)werechosenascontrolgroup．TheperipheralbloodNOX2andSODlevelsinpatientswithacutecerebralinfarctionandinobjectsofthecontrolgroupweremeasured24hours，3days，7days，14daysafterdiseaseattackweremeasuredbyusingWST一1re—d

6、uctionmethodandELISAmethod，respectively．ResultsPatientsofthecerebralinfarctiongrouphadmoresignificantlydecreasingperipheralbloodSODexpressionthanthecontrolgroupwithin24hours(P

7、bralinfarctiongroupwasstilllowerthanthecontrolgroup，buttherewasnotstatisticallysignifi—cantdifference(P>0．05)．TheNOX2valueofcerebralinfarctiongroupincreasedsignificantlywithin24hoursafterdiseaseattack(P

8、easingtonearnormalconditio