Cys-C在急性脑梗死并发SIRS致MODS患者中的水平变化-论文.pdf

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1、中风与神经疾病杂志2014年8月第31卷第8期·713·文章编号：1003—2754(2014)08-0713-03Cys—C在急性脑梗死并发SIRS致MODS患者中的水平变化张填，陈志斌，王琰，陈蓉摘要：目的观察胱抑素一c(Cystatin．C，Cys—C)在急性脑梗死(acutecerebralinfarction，ACI)并发全身炎症反应综合征(systemicinflammatoryresponsesyndrome，SIRS)致多器官功能障碍综合征(multipleorgandysfunetionsyn—drome，MODS)患者中的水平变化。方法A

2、CI患者278例根据其并发SIRS、MODS情况分为3组：SACI组166例、SIRS组47例、MODS组65例。同时，收集健康体检者50例作为正常对照组。采用免疫比浊法(PETIA)测定血清Cys—C水平，观察其与超敏C反应蛋白(hypersensitiveC—reactiveprotein，hs．CRP)、脂蛋白a(Lipoproteina，LPa)的相关性。结果与对照组比较，观察组各组血清Cys—C、LPa、hs—CRP水平均明显升高(P<0．01)，组间比较，SIRS、MODS组患者升高更为明显，以MODS组更为突出(P<0．05或P<0．叭)。相关

3、性分析表明，血清Cys—C水平与hs-CRP、LPa呈正相关。结论Cys—C与炎症反应关系密切，参与了ACI并发SIRS、MODS，并具有重要作用。关键词：Cys—C；急性脑梗死；SIRS；MODS中图分类号：R743．3文献标识码：AChangesofCys-CinacutecerebralinfarctionleadingtosystemicinflammatoryresponsesyndromewhichcausesmultipleorgandysfunctionsyndromeZHANGTian，CHENZhi—bin，WANGTan，eta1．(D

4、epartmentofNeurology，Affili—atedHospitalofHainanMedicalCollege，Haikou570102，China)Abstract：ObjectiveToobservechangesofCys—Cinacutecerebralinfarction(ACI)leadingtosystemicinflam·matoryresponsesyndrome(SIRS)whichcausesmuhipleorgandysfunctionsyndrome(MODS)．Methods278casesofAC1weredivi

5、dedintothreegroups：166casesweresimpleACI(SACIgroup)，47caseswereACIcompaniedwithSIRS(SIRSgroup)，65caseswereACIcompaniedwithMODS(MODSgroup)．50caseswerenormalcontrolgroup．PETIAmethodwasusedtomeasuretheserumCys—Clevels．ToanalyzethecorrelationbetweentheserumCys—Clevelsandhyper—sensitive

6、C—reactiveprotein(hs—CRP)andLipoprotein—a(LPa)levels．ResultsTheserumCys—C，hs—CRPandLPalevelsinpatientswithSACI，SIRSandMODSincreasedsignificantlycomparingtothoseinpatientsofthenormalcontrolgroup(P<0．01)．TheserumCys-C，LPaandhs-CRPlevelsinpatientswithMODSweresignificantlyhigherthantho

7、seinpatientswithSACI，SIRS(P<0．05orP<0．01)．ResultsofthecorrelationanalysisshowedthattheserumCys—Clevelswereposi—tivelycorrelatedtotheserulTlLPaandhs—CRPlevels．ConclusionsCys—Ciscloselyrelatedtoinflammation，mightplaysignificantroleinACIleadingtoSIRSwhichcausesMODS．Keywords：Cys—C；Acut

8、ecerebralinfarction；SIRS；M