白芷香豆素微囊的制备及其体外释药研究-论文.pdf

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1、第32卷第5期中华中医药学刊Vol_32No．52014年5月CHINESEARCHfVESOFTRADITIONALCHINESEMEDICINEMav2014DOI：10．13193／j．issn．1673-7717．2014．05．080白芷香豆素微囊的制备及其体外释药研究姜建伟，章红燕，何福根(浙江省肿瘤医院药剂科，浙江杭州310022)摘要：目的：研究白芷香豆素微囊的制备工艺，并考察其体外释药特性。方法：以包封率、载药量为指标，采用复凝聚法制备白芷香豆素微囊，用Doehlert设计法对白芷香豆素的制备工艺进行优化，用uV法测定

2、微囊在20h内溶出的量并作释放度考察曲线，且采用电镜对其形态与粒径进行考察。结果：白芷香豆素微囊的囊材囊心比、搅拌速度及体系的pH值对微囊的包封率与载药量均有显著影响，当囊材囊心比为4．3：1、搅拌速度为355r·rain～、pH值5．O时，制得的白芷香豆素微囊圆整光滑，无粘连，粒径均匀，包封率可高达77．74％，载药量为23．03％，囊径在200Ixm以下，且有一定的缓释作用。结论：复凝聚法制备白芷香豆素微囊工艺简单、可靠，产品稳定性好。关键词：白芷香豆素；微囊；Doehlert设计；复凝聚法；体外释药中图分类号：R283文献标志码：

3、A文章编号：1673—7717(2014)05—1197-03PreparationofAngelicaeDahuricaeCoumarinMicrocapsulesandStudyonItsReleaseBehaviorinvitroJIANGJianwei，ZHANGHongyan，HEFugen(PharmacyDepartment，ZhejiangProvincialTumorHospital，Hangzhou310022，Zhejiang，China)Abstract：0bjective：Tostudyandoptimizet

4、hepreparationtechnologyofAngelicaedahuricaeeoumannmicrocap·sules，andthentostudyitsreleasebehaviorinvitro．Methods：Takingtheencapsulationeficiencyanddrugloadingasin—dicators，theAngelicaedahuricaecoumarinmierocapsuleswerepreparedwiththecomplexagglutinationmethodandtheprepar

5、ationtechniqueofAngelicaedahuricaecoumarinmicrocapsuleswasoptimizedbyDoehlertdesign．ThedissolutionvolumeofAngelicaedahurieaecoumafinmicrocapsuleswithin20hoursandtheCHIVeofthereleasewasmeasuredbyul—travioletspectrophotometry，afterwardsitsmorphologyandparticlesizewerestudi

6、edbyelectronmicroscopy．Results：Theencapsulationratewassignificantlyrelatedtotheratioofcoatingmaterial，stirringspeedandthepH．ThehighestrateofproductionandtheminimaldiameterofmicrocapsuleswereobtainedwhentheratioofcoatingmaterialtoAngelicaedahu—rieaecoumarinwas4．3：1，thesti

7、rringspeedwas355revolutionsperminute，andthepHwas5．0．Theobtainedmicro—capsulesweresmoothroundcapsule—shaped，non—adhesions，withuniformparticlesize，andtheencapsulationeficiencywasupto77．74％，thedrugloading23．03％andthemicrocapsulediameterbelow200m，andcouldbeusedasthesustained

8、—releasepreparation．Conclusion：ComplexagglutinationusedtoprepareAngelicaedahuricaecoumafinmicro—capsule