他汀类药物对急性心肌梗死患者pci术后无复流的影响

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1、中国心血管病研究2010年8月第8卷第8期ChineseJournalofCardiovascularResearch，August2010，V01．8，No-8．561．他汀类药物对急性心肌梗死患者PCI术后无复流的影响Effectsofpre—-treatmentofstatinsonno-reflowphenomenoninAMIpatientsaftersuccessfulprimaryangioplasty丁超李俊峡赵玉英张莉汝磊生孙家安彭育红作者单位：050082河北省石家庄市，解放军自求恩国际和平医院心血管内科通讯作者：丁超，E-mail：dingch2001@so

2、hu．com【摘要】目的探讨急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术前应用他汀类药物对无复流及主要心脏不良事件(MACE)的影响。方法首次sT抬高型AMI发病12h内行直接PCI治疗的136例连续人院患者，按照术前是否服用他汀类药物分为他汀治疗组(40例)和非他汀治疗组(96例)。观察PCI术后无复流的发生情况。结果他汀组PCI术后无复流发生率明显低于非他汀组(12．5％比34．3％，P

3、CI术后1个月他汀组MACE发生率明显低于非他汀治疗组(12．5％比31_3％，P<0．01)。结论PCI术前应用他汀类药物可明显降低PCI术后无复流发生率，减少MACE发生，改善预后。【关键词】他汀；急性心肌梗死；经皮冠脉介入治疗；无复流doi：10．39690．issn．1672-5301．2010．08．001中图分类号17,542．2；R541．4文献标识码A文章编号1672—5301(2010)08-0561-03Efectsofpre-treatmentofstatinsonno-reflowphenomenoninAMIpatientsaftersuccessful

4、primaryangioplastyDINGChao，LIJun—xia，ZHAOYu—ying，eta1．DepartmentofCardiology，BethuneInternationalPeaceHospitalofpLA，Shijiazhuang050082，ChinaCorrespondingauthor：DINGChao，E-mail：dingch2001@sohu．com[Abstract]ObjectiveToevaluatetheefectofpre—．treatmentwithstatinonthedevelopmentoftheno——reflowandt

5、heincidenceofmainadvemecardiacevents(MACE)inpatientswhounderwentSUCCeSSfU]primarypercutanouscoronaryintervention(PCI)foracutemyocardialinfarction(AMI)．MethodsAtotalof136consecutiveAMIpatientsundergoingPC1weredividedintotwogroupsaccordingtowhetherusingstatinsornot．ResultsThe40patientsreceiving

6、long-termstatintreatmentbeforeadmissionhadlowerincidenceoftheno—reflowthanthosewithoutit(12．5％vs34_3％，P<0．01)．Logisticanalysesshowedthatabsenceofpre—treatmentwithstatinwasanindependentpredictorofno—reflow(RR3．56，95％C／1．59—4．58，P<0．05)．TheyalsoshowedlowerincidenceofMACE(12．5％VS31-3％。P<0．01)ins

7、tatingroupat1monthslater．CondusionPre—treatmentthstatincouldreducetheincidenceoftheno-reflowandMACEafterprimaryPCIinAMIpatients．[Keywords]Statins；Acutemyocardialinfarction；Percutanouscoronaryintervention；No—reflow急性心肌梗死(AMI)后梗死相关血管的早期、reflowp