慢性胃炎不同证型患者唾液EGF与胃黏膜细胞增殖的相关性.pdf

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1、第31卷第7期中华中医药学刊Vol．31No．72013年7月CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINEJul．2013地慢性胃炎不同证型患者唾液EGF与胃黏膜细胞增殖的相关性方张永锋，谭永港，张子理，杨敏，陈嫚茵项(深圳市第二人民医院，广东深圳518035)目摘要:目的:探讨慢性胃炎病证结合患者唾液EGF与胃黏膜细胞增殖的相关性。方法:慢性胃炎患者按辨宽证分为脾气虚组、胃阴虚组、脾胃湿热组、胃络瘀阻组;体检胃黏膜正常者为对照组，放免检测各组唾液EGF含带量，免疫组化染色观察胃黏膜细胞EGFR，c－Jun、PCNA的表达

2、水平。结果:脾胃湿热证及胃络瘀阻证组患者唾液EGF含量高于正常对照患者，EGFR，c－Jun、PCNA表达显著上调，差异均有统计学意义(P﹤0．05)。结论:唾液EGF含量水平与胃黏膜细胞增殖密切相关，慢性胃炎患者胃黏膜细胞增殖中医实证较虚证明显。关键词:慢性胃炎;中医证型;唾液;胃黏膜;细胞增殖中图分类号:R573．3文献标志码:B文章编号:1673－7717(2013)07－1669－02CorrelationBetweenSalivaEpidermalGrowthFactorandGastricMucosaCellProliferatinginPatient

3、swithChronicGastritisofDifferentTCMSyndromesZHANGYongfeng，TANYonggang，ZHANGZili，YANGMin，CHENManyin(ShenzhenSecondPeople＇sHospital，Shenzhen518035，Guangdong，China)Abstract:Objective:Toexploretheclinicalsignificanceofthecorrelationbetweensalivaepidermalgrowthfactot(EGF)andgastricmucosace

4、llproliferatinginpatientswithdifferentTCMsyndromes．Methods:Chronicgastritispatientswererandomizedintospleenqi－deficiencysyndrome，stomachyin－deficiencysyndrome，spleen－stomachdamp－heatsyndromeandstomachblood－stasissyndromegroups，gastricmucosanormalvolunteerwascontrolgroup．Thecontentofsa

5、livaEGFwasmeasuredbyradioimmunoassayandexpressionsofEGFR，c－JunandPCNAwereobservedbyimmunocy-tochemistryingastricmucosaofeachgroup．Results:ThecontentofsalivaEGFinspleen－stomachdamp－heatsyndromeandstomachblood－stasissyndromegroupwerehigherthanthoseincontrolgroup，andexpressionsofEGFR，c－J

6、unandPCNAwerenotablyincreased．Therewasstatisticalsignificanceindifference(P＜0．05)．Conclusion:ThereisaclosecorrelationbetweenthecontentofsalivaEGFandgastricmucosacellproliferating．ComparedwithTCMdeficiencysyn-drome，gastricmucosacellproliferatinginchronicgastritiswithTCMexcesssyndromeis

7、obvious．Keywords:chronicgastritis;TCMsyndrome;saliva;gastricmucosa;proliferatingcell望舌对慢性胃炎的辨证以及病情预后很有意义，素有炎20例。男34例，女26例，年龄21～47岁。对照组10例“舌为胃之镜”之说。已有研究表明:唾液表皮生长因子为体检胃黏膜正常者，其中男、女各5例，年龄21～43岁。(epidermalgrowthfactot，EGF)及舌苔表皮生长因子受体1．2诊断标准(epidermalgrowthfactorreceptor，EGFR)可能是影响慢性胃西医诊断标准

8、:慢性浅表